Interplay between diet and genetic susceptibility in obesity and related traits

被引：12

作者：

Wang, Tiange ^{[1
]}

Xu, Min ^{[1
]}

Bi, Yufang ^{[1
]}

Ning, Guang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Minist Hlth,Sch Med,Shanghai Inst Endocrine & Met, Natl Clin Res Ctr Metab Dis,Dept Endocrine & Meta, State Key Lab Med Genom,Ruijin Hosp,Key Lab Endoc, Shanghai 200025, Peoples R China

来源：

FRONTIERS OF MEDICINE | 2018年 / 12卷 / 06期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

diet; genetic susceptibility; obesity; interaction; WEIGHT-LOSS DIETS; POUNDS LOST; INSULIN-RESISTANCE; BODY-COMPOSITION; FAT DISTRIBUTION; BLOOD-PRESSURE; 2-YEAR CHANGES; FTO GENOTYPE; INTERVENTION; ASSOCIATION;

D O I：

10.1007/s11684-018-0648-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.

引用

页码：601 / 607

页数：7

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