Diabetic retinopathy is associated with subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus

被引：31

作者：

Son, Jang-Won ^{[1
]}

Jang, Eun-Hee ^{[1
]}

Kim, Mee-Kyoung ^{[1
]}

Kim, In Tae ^{[2
]}

Roh, Young Jung ^{[2
]}

Baek, Ki-Hyun ^{[1
]}

Song, Ki-Ho ^{[1
]}

Yoon, Kun-Ho ^{[1
]}

Cha, Bong-Yun ^{[1
]}

Lee, Kwang-Woo ^{[1
]}

Son, Ho-Young ^{[1
]}

Kwon, Hyuk-Sang ^{[1
]}

机构：

[1] Catholic Univ Korea, Dept Internal Med, St Marys Hosp, Div Endocrinol & Metab, Seoul 150713, South Korea

[2] Catholic Univ Korea, Dept Ophthalmol & Visual Sci, St Marys Hosp, Seoul 150713, South Korea

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2011年 / 91卷 / 02期

关键词：

Diabetic retinopathy; Carotid intima-media thickness; Atherosclerosis; CORONARY-HEART-DISEASE; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; ARTERY-DISEASE; RISK-FACTORS; EVENTS; MORTALITY; MEN;

D O I：

10.1016/j.diabres.2010.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: We aimed to evaluate the association between diabetic microangiopathy and subclinical atherosclerosis as a marker of cardiovascular disease (CVD) risk in patients with newly diagnosed type 2 diabetes. Methods: A total of 142 newly diagnosed type 2 diabetics who were free from CVD underwent evaluation of diabetic microangiopathy. Subclinical atherosclerosis was assessed by measuring carotid intima-media thickness (IMT), and the 10-year absolute risk of CVD was estimated using the UK Prospective Diabetes Study (UKPDS) Risk Engine. Results: Subclinical atherosclerosis was found in 27 subjects (19.0%). The rates of hypertension and diabetic retinopathy were significantly higher among patients with subclinical atherosclerosis. The UKPDS 10-year risk for CVD was significantly increased in subjects with subclinical atherosclerosis. Old age, hypertension and the presence of diabetic retinopathy showed a significant association to subclinical atherosclerosis after further adjustments for gender, body mass index, smoking status, HbA1c, HDL cholesterol, LDL cholesterol and the presence of diabetic nephropathy. Conclusions: This study shows that diabetic retinopathy is an independent risk marker for subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. We suggest that a diagnosis of diabetic retinopathy may warrant a more careful cardiovascular assessment even in the early stages of diabetes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：253 / 259

页数：7

共 32 条

[21]

Mancia G, 2007, EUR HEART J, V28, P1462, DOI [10.1093/eurheartj/ehm236, 10.1093/eurheartj/eht151]

[22] Retinopathy predicts coronary heart disease events in NIDDM patients [J].