BNT162b2 mRNA COVID-19 vaccine Reactogenicity: The key role of immunity

被引：15

作者：

Vizcarra, Pilar ^{[1
,4
]}

Haemmerle, Johannes ^{[2
]}

Velasco, Hector ^{[1
,3
,4
]}

Velasco, Tamara ^{[1
]}

Fernandez-Escribano, Marina ^{[2
]}

Vallejo, Alejandro ^{[1
,3
,4
]}

Casado, Jose L. ^{[1
,4
]}

机构：

[1] Hosp Univ Ramon y Cajal, Dept Infect Dis, Ctra Colmenar Km 9, Madrid 28034, Spain

[2] Hosp Univ Ramon y Cajal, Dept Prevent Occupat Risks, Ctra Colmenar Km 9, Madrid 28034, Spain

[3] Hosp Univ Ramon y Cajal, Lab Immunovirol, Madrid 28034, Spain

[4] Hosp Univ Ramon y Cajal, Inst Ramon y Cajal Invest Sanitarias IRYCIS, Ctra Colmenar Km 9, Madrid 28034, Spain

来源：

VACCINE | 2021年 / 39卷 / 51期

关键词：

SARS-CoV-2; COVID-19; BNT162b2 mRNA vaccine; Reactogenicity; T-cell responses; Booster effect;

D O I：

10.1016/j.vaccine.2021.10.074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the impact of pre-existing SARS-CoV-2-specific cellular immunity on BNT162b2 mRNA COVID-19 vaccine reactogenicity. Of 96 healthcare workers (HCWs), 76% reported any vaccine reaction (first dose: 70%, second dose: 67%), none of which was severe. Following first dose, systemic reactions were significantly more frequent among HCWs with past infection than in infection-naive individuals, and among HCWs with pre-existing cellular immunity than in those without it. The rate of systemic reactions after second dose was 1.7 and 2.0-times higher than after first dose among infection-naive HCWs and those without pre-existing cellular immunity, respectively. Levels of SARS-CoV-2-specific T-cells before vaccination were higher in HCWs with systemic reactions after the first dose than in those without them. BNT162b2 vaccine reactogenicity after first dose is attributable to pre-existing cellular immunity elicited by prior COVID-19 or cross-reactivity. Reactogenicity following second dose suggests an immunity-boosting effect. Overall, these data may reduce negative attitudes towards COVID-19 vaccines. Study Registration. The study was registered on clinicaltrials.gov, NCT04402827 . (c) 2021 Elsevier Ltd. All rights reserved .

引用

页码：7367 / 7374

页数：8

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