Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging

被引：58

作者：

Kopp, Felix K. ^{[1
]}

Daerr, Heiner ^{[2
]}

Si-Mohamed, Salim ^{[3
,4
]}

Sauter, Andreas P. ^{[1
]}

Ehn, Sebastian ^{[5
,6
]}

Fingerle, Alexander A. ^{[1
]}

Brendel, Bernhard ^{[2
]}

Pfeiffer, Franz ^{[5
,6
]}

Roessl, Ewald ^{[2
]}

Rummeny, Ernst J. ^{[1
]}

Pfeiffer, Daniela ^{[1
]}

Proksa, Roland ^{[2
]}

Douek, Philippe ^{[3
,4
]}

Noel, Peter B. ^{[1
,7
]}

机构：

[1] Tech Univ Munich, Dept Diagnost & Intervent Radiol, Munich, Germany

[2] Philips GmbH Innovat Technol, Res Labs, Hamburg, Germany

[3] Louis Pradel Univ Hosp, Dept Intervent Radiol & Cardiovasc & Thorac Diagn, Bron, France

[4] INSA Lyon, CNRS, INSERM, U1206,CREATIS,UMR 5220, Villeurbanne, France

[5] Tech Univ Munich, Dept Phys, Chair Biomed Phys, D-85748 Garching, Germany

[6] Tech Univ Munich, Munich Sch BioEngn, D-85748 Garching, Germany

[7] Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

欧盟地平线“2020”;

关键词：

HIGH-RESOLUTION CT; COMPUTED-TOMOGRAPHY; EXPERIMENTAL FEASIBILITY; CONTRAST AGENTS; LUNG-DISEASE; NODULES; CLASSIFICATION; QUALITY; ENERGY;

D O I：

10.1038/s41598-018-35888-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolution (HR-CT) mode. Volume estimation was evaluated by linear regression. Shape similarity was evaluated with the Dice similarity coefficient. Spatial resolution was investigated via MTF for each imaging system. In-vivo rabbit lung images from the SPCCT system were subjectively reviewed. Evaluating the volume estimation, linear regression showed best results for the SPCCT compared to CT and HR-CT with a root mean squared error of 21.3 mm(3), 28.5 mm(3) and 26.4 mm(3) for SPCCT, CT and HR-CT, respectively. The Dice similarity coefficient was superior for SPCCT throughout nodule shapes and all nodule sizes (mean, SPCCT: 0.90; CT: 0.85; HR-CT: 0.85). 10% MTF improved from 10.1 LP/cm for HR-CT to 21.7 LP/cm for SPCCT. Visual investigation of small pulmonary structures was superior for SPCCT in the animal study. In conclusion, the SPCCT prototype has the potential to improve the assessment of lung structures due to higher resolution compared to conventional CT.

引用

页数：9

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