Regulatory T cells in skin

被引：123

作者：

Ali, Niwa ^{[1
,2
]}

Rosenblum, Michael D. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[2] Kings Coll London, Cutaneous Med Unit, St Johns Inst Dermatol, London, England

来源：

IMMUNOLOGY | 2017年 / 152卷 / 03期

关键词：

autoimmunity; regulatory T cells; skin; MAINTAIN IMMUNE HOMEOSTASIS; TRANSCRIPTION FACTOR FOXP3; ALOPECIA-AREATA; INFLAMMATORY DISEASE; COMMENSAL MICROBES; DENDRITIC CELLS; SELF-TOLERANCE; HAIR-FOLLICLES; NEONATAL SKIN; P-SELECTIN;

D O I：

10.1111/imm.12791

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Foxp3(+) CD4(+) regulatory T (Treg) cells are a subset of immune cells that function to regulate tissue inflammation. Skin is one of the largest organs and is home to a large proportion of the body's Treg cells. However, relative to other tissues (such as the spleen and gastrointestinal tract) the function of Treg cells in skin is less well defined. Here, we review our understanding of how Treg cells migrate to skin and the cellular and molecular pathways required for their maintenance in this tissue. In addition, we outline what is known about the specialized functions of Treg cells in skin. Namely, the orchestration of stem cell-mediated hair follicle regeneration, augmentation of wound healing, and promoting adaptive immune tolerance to skin commensal microbes. A comprehensive understanding of the biology of skin Treg cells may lead to novel therapeutic approaches that preferentially target these cells to treat cutaneous autoimmunity, skin cancers and disorders of skin regeneration.

引用

页码：372 / 381

页数：10

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