Synthesis of Indenes by Intramolecular Morita-Baylis-Hillman Reaction in Aqueous Media Catalyzed by Resin-Supported Proline

被引：20
作者：
Akagawa, Kengo [1 ]
Sakamoto, Seiji [1 ]
Kudo, Kazuaki [1 ]
机构：
[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan
来源：
SYNLETT | 2011年 / 06期
关键词：
supported catalysis; annulation; aldehydes; proline; Morita-Baylis-Hillman reaction; ASYMMETRIC TRANSFER HYDROGENATION; EFFICIENT SYNTHESIS; FUNCTIONALIZED INDENES; RADICAL CYCLIZATION; RATE ACCELERATION; PEPTIDE CATALYST; AROMATIC KETONES; TANDEM REACTIONS; 3+2 ANNULATION; ALKYNES;
D O I：
10.1055/s-0030-1259683
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel synthesis of indene derivatives has been developed in an organocatalytic way. Although homogeneous proline showed low catalytic efficiency, resin-supported proline effectively catalyzed the intramolecular Morita-Baylis-Hillman reaction to afford the desired indenes.
引用
收藏
页码：817 / 820
页数：4
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