The role of subunit interfaces for the nicotinic acetylcholine receptor's allosterism

被引：0

作者：

Hucho, F

Methfessel, C

Watty, A

机构：

[1] Free Univ Berlin, Inst Biochem, D-14195 Berlin, Germany

[2] Bayer AG, Biophys Abt, Zentrale Forsch, D-51368 Leverkusen, Germany

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 02期

关键词：

acetylcholine receptor; allosterism; quaternary structure; cross-linking;

D O I：

10.1016/S0928-4257(98)80143-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cross-linking of nicotinic acetylcholine receptors, combined with binding studies and patch-clamp electrophysiology, has proven the existence of a 'pre-existing equilibrium' of functional states and the functional role of subunit interfaces, two key postulates of the allosteric model. ((C) Elsevier, Paris).

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页码：85 / 88

页数：4

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