Mouse paw edema induced by a novel bradykinin agonist and its inhibition by B2-antagonists

被引：9

作者：

Ueno, A ^{[1
]}

Naraba, H ^{[1
]}

Oh-ishi, S ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Dept Pharmacol, Minato Ku, Tokyo 1088641, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 78卷 / 01期

关键词：

bradykinin B2-receptor agonist; FR190997; mouse paw edema;

D O I：

10.1254/jjp.78.109

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel non-peptide bradykinin B2-receptor agonist, FR190997 (8-[2,6-dichloro-3-[N-[(E)-4-(N-methylcarbamoyl) cinnamidoacetyl]-N-methylamino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy) quinoline), induced dose-dependent and longer-lasting swelling than bradykinin in the mouse paw. The swelling, peaking around 30 min, was suppressed dose-dependently by intraperitoneal administration of FR173657, a novel non-peptide B2-receptor antagonist. A known B2-antagonist, Hoe 140, also significantly suppressed this edema. The result indicates that the novel B2-agonist FR190997, being more stable than bradykinin, could induce plasma exudation locally in mice via the B2-receptor as a substitute for bradykinin.

引用

页码：109 / 111

页数：3