Effect of Narrow-band UVB Phototherapy on Soluble Cell Adhesion Molecules in Patients with Psoriasis Vulgaris

被引：8

作者：

Long, J. W. ^{[1
]}

Tao, J. ^{[1
]}

Pi, X. M. ^{[2
]}

Wang, Y. Y. ^{[2
]}

Tu, Y. T. ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Dermatol, Wuhan 430022, Hubei, Peoples R China

[2] Hubei Univ Tradit Chinese Med, Affiliated Hosp, Dept Dermatol, Wuhan, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2010年 / 38卷 / 04期

关键词：

NARROW-BAND ULTRAVIOLET B (NB-UVB); PHOTOTHERAPY; PSORIASIS VULGARIS; SOLUBLE CELL ADHESION MOLECULES; PSORIASIS AREA AND SEVERITY INDEX (PASI); TUMOR-NECROSIS-FACTOR; SERUM L-SELECTIN; ENDOTHELIAL-CELLS; ATOPIC-DERMATITIS; DISEASE-ACTIVITY; P-SELECTIN; T-CELLS; EXPRESSION; PLASMA; LEUKOCYTES;

D O I：

10.1177/147323001003800434

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study investigated the effect of narrow-band ultraviolet B (NB-UVB) phototherapy on serum levels of the soluble cell adhesion molecules sE-selectin, sP-selectin, sL-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) in 58 patients with psoriasis vulgaris. Psoriasis Area and Severity Index (PASI) scores significantly decreased after treatment, confirming the efficacy of NB-UVB phototherapy. Serum levels of sE-selectin also decreased significantly after treatment, and levels of sICAM-1 showed a significant correlation with PASI score and with levels of sE-selectin. The efficacy of NB-UVB phototherapy in improving psoriatic lesions may be a function of decreased serum levels of E-selectin. These findings emphasize the complex roles of soluble cell adhesion molecules in the immunopathogenesis of psoriasis.

引用

页码：1507 / 1512

页数：6

共 30 条

[1] IDENTIFICATION OF AN INDUCIBLE ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE [J].