NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer

被引：5

作者：

Espinosa, Lluis ^{[1
]}

Marruecos, Laura ^{[1
]}

机构：

[1] Hosp Mar, Inst Mar Invest Med, CIBERONC, Canc Res Program, Doctor Aiguader 88, Barcelona 08003, Spain

来源：

BIOMEDICINES | 2021年 / 9卷 / 09期

关键词：

I kappa B alpha; SUMOylation; NF-kappa B; polycomb repression complex (PRC) 2; cancer; NUCLEAR IKK ACTIVITY; CELL LYMPHOMA; TYROSINE PHOSPHORYLATION; GENE-EXPRESSION; NASOPHARYNGEAL CARCINOMA; CONSTITUTIVE ACTIVATION; NFKBIA POLYMORPHISM; COLORECTAL-CANCER; PROSTATE-CANCER; GROWTH-FACTOR;

D O I：

10.3390/biomedicines9091278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

I kappa B alpha is considered to play an almost exclusive role as inhibitor of the NF-kappa B signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-kappa B-binding affinity and function to the I kappa B alpha protein. In this review we discuss the main alterations of I kappa B alpha found in cancer and whether they are (most likely) associated with NF-kappa B-dependent or NF-kappa B-independent (moonlighting) activities of the protein.

引用

页数：11

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