Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery

被引：57
作者：
Jelonek, Katarzyna [1 ]
Li, Suming [2 ]
Wu, Xiaohan [3 ]
Kasperczyk, Janusz [1 ,4 ,5 ]
Marcinkowski, Andrzej [1 ]
机构：
[1] Polish Acad Sci, Ctr Polymer & Carbon Mat, PL-41819 Zabrze, Poland
[2] Univ Montpellier 2, European Inst Membranes, UMR CNRS 5635, F-34095 Montpellier 5, France
[3] Univ Montpellier I, Max Mousseron Inst Biomol, UMR CNRS 5247, F-34095 Montpellier 5, France
[4] Med Univ Silesia, Sch Pharm, Div Lab Med Sosnowiec, Katowice, Poland
[5] Dept Biopharm, Sosnowiec, Poland
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2015年 / 485卷 / 1-2期
关键词：
Polymeric micelles; Filomicelles; Paclitaxel; PLA/PEG; Drug delivery; MICELLES; PACLITAXEL; VISUALIZATION; MORPHOLOGIES; BEHAVIOR;
D O I：
10.1016/j.ijpharm.2015.03.032
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bioresorbable filomicelles present many advantageous as drug delivery systems e.g., long circulation time and high loading efficiency. The aim of this study was to develop polylactide/poly(ethylene glycol) (PLA/PEG) filomicelles for drug delivery applications. A series of PLA/PEG diblock copolymers were synthesized using non-toxic initiator, and characterized by means of NMR and GPC. Analysis of morphology of micelles determined by TEM revealed that apart from the weight fraction also the molar mass of PEG and the stereochemistry of PLA block must be considered for tailoring micellar structures. The CMC was found to be dependent on the length and structure of the hydrophobic block. It was observed that the drug loading properties could be improved by selection of appropriate copolymer and encapsulation method. Slower release of paclitaxel was observed for mPEG5000 initiated copolymers than mPEG2000 initiated copolymers. Moreover, the influence of the length of hydrophobic block and its stereoisomeric form on drug release rate was evidenced. Therefore, PLA/PEG filomicelles with good stability, high drug loading capacity and sustained drug release appear most attractive for drug delivery applications. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：357 / 364
页数：8
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