Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe

被引:63
作者
Villeneuve, Sara [1 ,2 ]
Cyr, Diane [2 ]
Lynge, Elsebeth [3 ]
Orsi, Laurent [2 ]
Sabroe, Svend [4 ]
Merletti, Franco [5 ,17 ]
Gorini, Giuseppe [6 ]
Morales-Suarez-Varela, Maria [7 ,8 ,9 ]
Ahrens, Wolfgang [10 ]
Baumgardt-Elms, Cornelia [11 ]
Kaerlev, Linda [12 ]
Eriksson, Mikael [13 ]
Hardell, Lennart [14 ]
Fevotte, Joelle [15 ,16 ]
Guenel, Pascal [2 ,16 ]
机构
[1] INSERM, CESP, U1018, F-94807 Villejuif, France
[2] Univ Paris 11, Paris, France
[3] Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark
[4] Univ Aarhus, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark
[5] Univ Turin, CERMS, Canc Epidemiol Unit, Piemonte, Italy
[6] ISPO Canc Prevent & Res Inst, Environm & Occupat Epidemiol Unit, Florence, Italy
[7] Univ Valencia, Dept Prevent Med, Unit Publ Hlth & Environm Care, Valencia, Spain
[8] CIBER Act Epidemiol & Publ Hlth, Res Grp CIBER CB06 02 0045, Valencia, Spain
[9] Univ Hosp Dr Peset, Res Fdn, Valencia, Spain
[10] Bremen Inst Prevent Res & Social Med, Bremen, Germany
[11] Hamburg Canc Registry, Hamburg, Germany
[12] Odense Univ Hosp, Ctr Natl Clin Databases S, Dept Res & HTA, DK-5000 Odense, Denmark
[13] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
[14] Orebro Univ Hosp, Dept Oncol, Orebro, Sweden
[15] Univ Lyon 1, InVS, INRETS, UMRESTTE, F-69365 Lyon, France
[16] InVS Inst Hlth Surveillance, Dept Occupat Hlth DST, St Maurice, France
[17] CPO, Piemonte, Italy
关键词
POLYCHLORINATED-BIPHENYLS; RISK-FACTORS; ENVIRONMENTAL-POLLUTANTS; ELECTROMAGNETIC-FIELDS; EPIDEMIOLOGIC EVIDENCE; CYTOCHROME-P450; 1A1; ORGANIC-SOLVENTS; NORTH-CAROLINA; WOMEN; MEN;
D O I
10.1136/oem.2009.052175
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objectives Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. Methods Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement. Results Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens. Conclusion These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer.
引用
收藏
页码:837 / 844
页数:8
相关论文
共 52 条
[41]   Endocrine disrupting chemicals in indoor and outdoor air [J].
Rudel, Ruthann A. ;
Perovich, Laura J. .
ATMOSPHERIC ENVIRONMENT, 2009, 43 (01) :170-181
[42]   COSTS AND STATISTICAL POWER ASSOCIATED WITH 5 METHODS OF COLLECTING OCCUPATION EXPOSURE INFORMATION FOR POPULATION-BASED CASE-CONTROL STUDIES [J].
SIEMIATYCKI, J ;
DEWAR, R ;
RICHARDSON, L .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 130 (06) :1236-1246
[43]   Occupational Exposure to Polychlorinated Biphenyls and Risk of Breast Cancer [J].
Silver, Sharon R. ;
Whelan, Elizabeth A. ;
Deddens, James A. ;
Steenland, N. Kyle ;
Hopf, Nancy B. ;
Waters, Martha A. ;
Ruder, Avima M. ;
Prince, Mary M. ;
Yong, Lee C. ;
Hein, Misty J. ;
Ward, Elizabeth M. .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2009, 117 (02) :276-282
[44]   THE E-SCREEN ASSAY AS A TOOL TO IDENTIFY ESTROGENS - AN UPDATE ON ESTROGENIC ENVIRONMENTAL-POLLUTANTS [J].
SOTO, AM ;
SONNENSCHEIN, C ;
CHUNG, KL ;
FERNANDEZ, MF ;
OLEA, N ;
SERRANO, FO .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1995, 103 :113-122
[45]   Occupational exposure to magnetic fields in relation to male breast cancer and testicular cancer: A Swedish case-control study [J].
Stenlund, C ;
Floderus, B .
CANCER CAUSES & CONTROL, 1997, 8 (02) :184-191
[46]   Light-at-night, circadian disruption and breast cancer: assessment of existing evidence [J].
Stevens, Richard G. .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2009, 38 (04) :963-970
[47]   BREAST-CANCER IN MEN - RISK-FACTORS WITH HORMONAL IMPLICATIONS [J].
THOMAS, DB ;
JIMENEZ, LM ;
MCTIERNAN, A ;
ROSENBLATT, K ;
STALSBERG, H ;
STEMHAGEN, A ;
THOMPSON, WD ;
CURNEN, MGM ;
SATARIANO, W ;
AUSTIN, DF ;
GREENBERG, RS ;
KEY, C ;
KOLONEL, LN ;
WEST, DW .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 135 (07) :734-748
[48]   ELECTROMAGNETIC-FIELDS AND MALE BREAST-CANCER [J].
TYNES, T ;
ANDERSEN, A .
LANCET, 1990, 336 (8730) :1596-1596
[49]   A job-exposure matrix for potential endocrine-disrupting chemicals developed for a study into the association between maternal occupational exposure and hypospadias [J].
Van Tongeren, M ;
Nieuwenhuijsen, MJ ;
Gardiner, K ;
Armstrong, B ;
Vrijheid, M ;
Dolk, H ;
Botting, B .
ANNALS OF OCCUPATIONAL HYGIENE, 2002, 46 (05) :465-477
[50]   Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study [J].
Warner, M ;
Eskenazi, B ;
Mocarelli, P ;
Gerthoux, PM ;
Samuels, S ;
Needham, L ;
Patterson, D ;
Brambilla, P .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2002, 110 (07) :625-628