Biliary differentiation and bile duct morphogenesis in development and disease

被引：103

作者：

Raynaud, Peggy ^{[1
]}

Carpentier, Rodolphe ^{[1
]}

Antoniou, Aline ^{[1
]}

Lemaigre, Frederic P. ^{[1
]}

机构：

[1] Catholic Univ Louvain, de Duve Inst, B-1200 Brussels, Belgium

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2011年 / 43卷 / 02期

关键词：

Cholangiocyte; Hepatic artery; Hepatoblast; Liver development; Polycystic disease; POLYCYSTIC KIDNEY-DISEASE; MECKEL-GRUBER-SYNDROME; CONGENITAL HEPATIC-FIBROSIS; CHOLANGIOCYTE PRIMARY CILIA; NOTCH RECEPTOR EXPRESSION; TRANSCRIPTION FACTOR HNF6; ENDOTHELIAL GROWTH-FACTOR; HUMAN LIVER DEVELOPMENT; CELL FATE DECISION; HOMEOBOX GENE HEX;

D O I：

10.1016/j.biocel.2009.07.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biliary tract consists of a network of intrahepatic and extrahepatic ducts that collect and drain the bile produced by hepatocytes to the gut. The bile ducts are lined by cholangiocytes, a specialized epithelial cell type that has a dual origin. Intrahepatic cholangiocytes derive from the liver precursor cells, whereas extrahepatic cholangiocytes are generated directly from the endoderm. In this review we discuss the mechanisms of cholangiocyte differentiation and bile duct morphogenesis, and describe how developing ducts interact with the hepatic artery. We also present an overview of the mechanisms of biliary dysgenesis in humans. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：245 / 256

页数：12

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