Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness
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作者:
Tee, Shang-You
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机构:
Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USAUniv Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Tee, Shang-You
[1
]
Fu, Jianping
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机构:
Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Fu, Jianping
[1
,2
]
Chen, Christopher S.
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机构:
Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Chen, Christopher S.
[1
,2
]
Janmey, Paul A.
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机构:
Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Univ Penn, Dept Phys, Philadelphia, PA 19104 USA
Univ Penn, Dept Physiol, Philadelphia, PA 19104 USAUniv Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
Janmey, Paul A.
[1
,2
,3
,4
]
机构:
[1] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Phys, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA
Cells from many different tissues sense the stiffness and spatial patterning of their microenvironment to modulate their shape and cortical stiffness. It is currently unknown how substrate stiffness, cell shape, and cell stiffness modulate or interact with one another. Here, we use microcontact printing and microfabricated arrays of elastomeric posts to independently and simultaneously control cell shape and substrate stiffness. Our experiments show that cell cortical stiffness increases as a function of both substrate stiffness and spread area. For soft substrates, the influence of substrate stiffness on cell cortical. stiffness is more prominent than that of cell shape, since increasing adherent area does not lead to cell stiffening. On the other hand, for cells constrained to a small area, cell shape effects are more dominant than substrate stiffness, since increasing substrate stiffness no longer affects cell stiffness. These results suggest that cell size and substrate stiffness can interact in a complex fashion to either enhance or antagonize each other's effect on cell morphology and mechanics.
机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Saez, Alexandre
Trichet, Lea
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Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Trichet, Lea
Xayaphoummine, Alain
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机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Xayaphoummine, Alain
Browaeys, Julien
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机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Browaeys, Julien
Silberzan, Pascal
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机构:
Univ Paris 06, Inst Curie, Ctr Rech, Lab Physicochim Curie,CNRS UMR 168, F-75248 Paris 05, FranceUniv Paris Diderot, F-75205 Paris 13, France
机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Saez, Alexandre
Trichet, Lea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Trichet, Lea
Xayaphoummine, Alain
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h-index: 0
机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Xayaphoummine, Alain
Browaeys, Julien
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Diderot, F-75205 Paris 13, France
CNRS, Lab Mat & Syst Complexes MSC, UMR 7057, F-75205 Paris 13, FranceUniv Paris Diderot, F-75205 Paris 13, France
Browaeys, Julien
Silberzan, Pascal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Inst Curie, Ctr Rech, Lab Physicochim Curie,CNRS UMR 168, F-75248 Paris 05, FranceUniv Paris Diderot, F-75205 Paris 13, France