Vanadium(III) chloride (VCl3):: Efficient reagent for the introduction of tetrahydrofuran-based acetal protecting groups for alcohols

被引：15

作者：

Das, Biswanath ^{[1
]}

Krishnaiah, Maddeboina ^{[1
]}

Reddy, Vtukuri Saidi ^{[1
]}

Laxminarayana, Keetha ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

HELVETICA CHIMICA ACTA | 2007年 / 90卷 / 11期

关键词：

D O I：

10.1002/hlca.200790223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of different types of alcohols with tetrahydrofuran (THF) in the presence of VCl3 and CCl4 smoothly afforded the corresponding THF-based acetals in excellent yields. The reaction is fast at room temperature, and several functional groups are tolerated, with no racemization being observed. A radical mechanism, based on Cl3C center dot as the active species, is proposed for this novel kind of transformation, which complements the classical tetrahydro-2H-pyran-2-yl (THP) protocol.

引用

页码：2163 / 2166

页数：4

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