Crystal structure of (3E,5E)-3,5-bis(4-fluorobenzylidene)-1-((4-trifluoromethyl) benzenesulfonyl)piperidin-4-one, C26H18F5NO3S

被引:0
作者
Gao, Zhong-Fei [1 ]
Wang, Lei [1 ]
Hou, Gui-Ge [1 ]
Zhang, Xiao-Fan [1 ]
机构
[1] Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat, State Adm Tradit Chinese Med China, Yantai 264003, Peoples R China
来源
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES | 2021年 / 236卷 / 06期
关键词
3,5-BIS(ARYLIDENE)-4-PIPERIDONES; DERIVATIVES; ANTITUMOR; AGENTS;
D O I
10.1515/ncrs-2021-0300
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
C26H18F5NO3S, triclinic, P (1) over bar (no. 2), a = 7.8831(4) angstrom, b = 11.9591(7) angstrom, c = 13.3258(7) angstrom, alpha = 69.072(5)degrees, beta = 88.556(4)degrees, gamma = 73.730(5)degrees, V = 1122.48(11) angstrom(3), Z = 2, R-gt(F) = 0.0507, wR(ref)(F-2) = 0.1216, T = 100.0(1) K.
引用
收藏
页码:1275 / 1278
页数:4
相关论文
共 21 条
[1]  
Damayanti Prashinta Nita, 2020, Research Journal of Pharmacy and Technology, V13, P4765, DOI 10.5958/0974-360X.2020.00838.0
[2]   Fluorinated porphyrinoids and their biomedical applications [J].
Goslinski, T. ;
Piskorz, J. .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS, 2011, 12 (04) :304-321
[3]   The many roles for fluorine in medicinal chemistry [J].
Hagmann, William K. .
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (15) :4359-4369
[4]   Synthesis of N-Substituted 3,5-Bis(arylidene)-4-piperidones with High Antitumor and Antioxidant Activity [J].
Kalai, Tamas ;
Kuppusamy, M. Lakshmi ;
Balog, Maria ;
Selvendiran, Karuppaiyah ;
Rivera, Brian K. ;
Kuppusamy, Periannan ;
Hideg, Kalman .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (15) :5414-5421
[5]   Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects [J].
Kotha, Raghavendhar R. ;
Luthria, Devanand L. .
MOLECULES, 2019, 24 (16)
[6]   N-phenylsulfony1-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines [J].
Li, Ning ;
Xin, Wen-Yu ;
Yao, Bin-Rong ;
Cong, Wei ;
Wang, Chun-Hua ;
Hou, Gui-Ge .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 155 :531-544
[7]   Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues [J].
Liang, Guang ;
Yang, Shulin ;
Zhou, Huiping ;
Shao, Lili ;
Huang, Kexin ;
Xiao, Jian ;
Huang, Zhifeng ;
Li, Xiaokun .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (02) :915-919
[8]   3,5-Bis(2-fluorobenzylidene)-4-piperidone induce reactive oxygen species-mediated apoptosis in A549 cells [J].
Liu, Guo-Yun ;
Jia, Cong-Cong ;
Han, Pu-Ren ;
Yang, Jie .
MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (01) :128-136
[9]   Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells [J].
Ocasio-Malave, Carlimar ;
Donate, Metsiel J. ;
Sanchez, Maria M. ;
Sosa-Rivera, Jesus M. ;
Mooney, Joseph W. ;
Pereles-De Leon, Tomas A. ;
Carballeira, Nestor M. ;
Zayas, Beatriz ;
Velez-Gerena, Christian E. ;
Martinez-Ferrer, Magaly ;
Sanabria-Rios, David J. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (01)
[10]   3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors [J].
Osman, Hasnah ;
Idris, Nor Hashima ;
Kamarulzaman, Ezatul Ezleen ;
Wahab, Habibah A. ;
Hassan, Mohd. Zaheen .
ACTA PHARMACEUTICA SINICA B, 2017, 7 (04) :479-484