Outer membrane vesicles function as offensive weapons in host-parasite interactions

被引:113
作者
Amano, Atsuo [1 ]
Takeuchi, Hiroki [1 ]
Furuta, Nobumichi [1 ]
机构
[1] Osaka Univ, Grad Sch Dent, Dept Oral Frontier Biol, Suita, Osaka 5650871, Japan
关键词
Outer membrane vesicles; Gram-negative bacteria; Host-parasite interaction; Porphyromonas gingivalis; GRAM-NEGATIVE BACTERIA; PORPHYROMONAS-GINGIVALIS; PSEUDOMONAS-AERUGINOSA; HELICOBACTER-PYLORI; EXTRACELLULAR VESICLES; SHIGA TOXIN; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; MORAXELLA-CATARRHALIS; SECRETION PATHWAY; EPITHELIAL-CELLS;
D O I
10.1016/j.micinf.2010.05.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Outer membrane vesicles (OMVs), ubiquitously shed from Gram-negative bacteria, contain various virulence factors such as toxins, proteases, adhesins, and lipopolysaccharide, which are utilized to establish a colonization niche, modulate host defense and response, and impair host cell function. Thus, OMVs can be considered as a type of bacterial offensive weapon. This review discusses the entry mechanism of OMVs into host cells as well as their etiological roles in host-parasite interactions. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:791 / 798
页数:8
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