Metaplasia in the Stomach-Precursor of Gastric Cancer?

被引：76

作者：

Kinoshita, Hiroto ^{[1
]}

Hayakawa, Yoku ^{[1
]}

Koike, Kazuhiko ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 10期

关键词：

gastric cancer; intestinal metaplasia; Spasmolytic polypeptide expressing metaplasia (SPEM); Helicobacter pylori; stem cells; lineage tracing; HELICOBACTER-PYLORI CAGA; NF-KAPPA-B; POLYPEPTIDE-EXPRESSING METAPLASIA; STEM-CELL NICHE; INTESTINAL METAPLASIA; EPITHELIAL-CELLS; TRANSGENIC MICE; CHIEF CELLS; MOUSE STOMACH; IV SECRETION;

D O I：

10.3390/ijms18102063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Helicobacter pylori infection via the Correa pathway: the progression is from gastritis, atrophy, intestinal metaplasia, dysplasia, to cancer. However, it remains unclear whether metaplasia is a direct precursor of gastric cancer or merely a marker of high cancer risk. Here, we review human studies on the relationship between metaplasia and cancer in the stomach, data from mouse models of metaplasia regarding the mechanism of metaplasia development, and the cellular responses induced by H. pylori infection.

引用

页数：16

共 156 条

[51] Morphogens and the Parietal Cell: Shaping Up Acid Secretion [J].

Heijmans, Jarom ;

van den Brink, Gijs R. .

GASTROENTEROLOGY, 2010, 139 (06) :1830-1833

[52] LOSS OF DIFFERENTIATION IN INTESTINAL METAPLASIA IN CANCEROUS STOMACHS - COMPARATIVE MORPHOLOGIC STUDY [J].

HEILMANN, KL ;

HOPKER, WW .

PATHOLOGY RESEARCH AND PRACTICE, 1979, 164 (03) :249-258

[53] SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein [J].

Higashi, H ;

Tsutsumi, R ;

Muto, S ;

Sugiyama, T ;

Azuma, T ;

Asaka, M ;

Hatakeyama, M .

SCIENCE, 2002, 295 (5555) :683-686

[54] Helicobacter pylori induces IκB kinase at nuclear translocation and chemokine production in gastric epithelial cells [J].

Hirata, Y ;

Maeda, S ;

Ohmae, T ;

Shibata, W ;

Yanai, A ;

Ogura, K ;

Yoshida, H ;

Kawabe, T ;

Omata, M .

INFECTION AND IMMUNITY, 2006, 74 (03) :1452-1461

[55] Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation [J].

Hirata, Y ;

Maeda, S ;

Mitsuno, Y ;

Tateishi, K ;

Yanai, A ;

Akanuma, M ;

Yoshida, H ;

Kawabe, T ;

Shiratori, Y ;

Omata, M .

GASTROENTEROLOGY, 2002, 123 (06) :1962-1971

[56] Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells [J].

Hirata, Y ;

Maeda, S ;

Mitsuno, W ;

Akanuma, M ;

Yamaji, Y ;

Ogura, K ;

Yoshida, H ;

Shiratori, Y ;

Omata, M .

INFECTION AND IMMUNITY, 2001, 69 (06) :3965-3971

[57] MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells [J].

Hirata, Yoshihiro ;

Ohmae, Tomoya ;

Shibata, Wataru ;

Maeda, Shin ;

Ogura, Keiji ;

Yoshida, Haruhiko ;

Kawabe, Takao ;

Omata, Masao .

JOURNAL OF IMMUNOLOGY, 2006, 176 (06) :3796-3803

[58] Gastric cancer originating from bone marrow-derived cells [J].

Houghton, J ;

Stoicov, C ;

Nomura, S ;

Rogers, AB ;

Carlson, J ;

Li, HC ;

Cai, X ;

Fox, JG ;

Goldenring, JR ;

Wang, TC .

SCIENCE, 2004, 306 (5701) :1568-1571

[59] Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach [J].

Huh, Won Jae ;

Khurana, Shradha S. ;

Geahlen, Jessica H. ;

Kohli, Kavita ;

Waller, Rachel A. ;

Mills, Jason C. .

GASTROENTEROLOGY, 2012, 142 (01) :21-U105

[60] Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma [J].

Kakiuchi, Miwako ;

Nishizawa, Takashi ;

Ueda, Hiroki ;

Gotoh, Kengo ;

Tanaka, Atsushi ;

Hayashi, Akimasa ;

Yamamoto, Shogo ;

Tatsuno, Kenji ;

Katoh, Hiroto ;

Watanabe, Yoshiaki ;

Ichimura, Takashi ;

Ushiku, Tetsuo ;

Funahashi, Shinichi ;

Tateishi, Keisuke ;

Wada, Ikuo ;

Shimizu, Nobuyuki ;

Nomura, Sachiyo ;

Koike, Kazuhiko ;

Seto, Yasuyuki ;

Fukayama, Masashi ;

Aburatani, Hiroyuki ;

Ishikawa, Shumpei .

NATURE GENETICS, 2014, 46 (06) :583-587

← 1 2 3 4 5 6 7 8 9 10 →