RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing

被引:57
作者
Webb, Laurence G. [1 ,2 ]
Fernandez-Sesma, Ana [1 ,2 ]
机构
[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
[2] Mt Sinai Dept Microbiol, New York, NY 10029 USA
关键词
CYCLIC GMP-AMP; PAPAIN-LIKE PROTEASE; RIG-I; DNA; 2ND-MESSENGER; ADAPTER; NS4B; REVEALS; TRIGGER; ROLES;
D O I
10.1016/j.coviro.2022.101206
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The past decade has provided critical information about the cytoplasmic innate immune sensing pathway of cyclic GMPA-MP synthase (cGAS) and stimulator of interferon genes (STING). These discoveries have broadened our understanding of the interconnectedness of the cGAS-STING pathway with autophagy, programmed cell death, Rig-I-like receptor (RLR) signaling, DNA independent interferon induction, and how this pathway responds to RNA virus infection. These advances highlight how multiple families of RNA viruses are restricted by and in turn have mechanisms to inhibit cGAS-STING dependent type-I interferon (IFN-I) induction. Here we review recent discoveries of how and why the cGAS-STING pathway responds to infection with RNA viruses, novel findings of RNA viral antagonism of the cGAS-STING innate immune sensing pathway, and attempt to provide context for a shift in thinking as to how critical this DNA sensing pathway is for the restriction of a wide range of RNA viruses.
引用
收藏
页数:8
相关论文
共 57 条
[1]   cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING [J].
Ablasser, Andrea ;
Goldeck, Marion ;
Cavlar, Taner ;
Deimling, Tobias ;
Witte, Gregor ;
Roehl, Ingo ;
Hopfner, Karl-Peter ;
Ludwig, Janos ;
Hornung, Veit .
NATURE, 2013, 498 (7454) :380-+
[2]   Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection [J].
Aguirre, Sebastian ;
Luthra, Priya ;
Sanchez-Aparicio, Maria T. ;
Maestre, Ana M. ;
Patel, Jenish ;
Lamothe, Francise ;
Fredericks, Anthony C. ;
Tripathi, Shashank ;
Zhu, Tongtong ;
Pintado-Silva, Jessica ;
Webb, Laurence G. ;
Bernal-Rubio, Dabeiba ;
Solovyov, Alexander ;
Greenbaum, Benjamin ;
Simon, Viviana ;
Basler, Christopher F. ;
Mulder, Lubbertus C. F. ;
Garcia-Sastre, Adolfo ;
Fernandez-Sesma, Ana .
NATURE MICROBIOLOGY, 2017, 2 (05)
[3]   DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING [J].
Aguirre, Sebastian ;
Maestre, Ana M. ;
Pagni, Sarah ;
Patel, Jenish R. ;
Savage, Timothy ;
Gutman, Delia ;
Maringer, Kevin ;
Bernal-Rubio, Dabeiba ;
Shabman, Reed S. ;
Simon, Viviana ;
Rodriguez-Madoz, Juan R. ;
Mulder, Lubbertus C. F. ;
Barber, Glen N. ;
Fernandez-Sesma, Ana .
PLOS PATHOGENS, 2012, 8 (10)
[4]   cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders [J].
Andreeva, Liudmila ;
Hiller, Bjoern ;
Kostrewa, Dirk ;
Laessig, Charlotte ;
Mann, Carina C. de Oliveira ;
Drexler, David Jan ;
Maiser, Andreas ;
Gaidt, Moritz ;
Leonhardt, Heinrich ;
Hornung, Veit ;
Hopfner, Karl-Peter .
NATURE, 2017, 549 (7672) :394-+
[5]   LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling [J].
Bruns, Annie M. ;
Horvath, Curt M. .
CYTOKINE, 2015, 74 (02) :198-206
[6]   SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex [J].
Chen, Xiaojuan ;
Yang, Xingxing ;
Zheng, Yang ;
Yang, Yudong ;
Xing, Yaling ;
Chen, Zhongbin .
PROTEIN & CELL, 2014, 5 (05) :369-381
[7]   Autophagy during viral infection - a double-edged sword [J].
Choi, Younho ;
Bowman, James W. ;
Jung, Jae U. .
NATURE REVIEWS MICROBIOLOGY, 2018, 16 (06) :340-353
[8]   Structural mechanism of cytosolic DNA sensing by cGAS [J].
Civril, Filiz ;
Deimling, Tobias ;
Mann, Carina C. de Oliveira ;
Ablasser, Andrea ;
Moldt, Manuela ;
Witte, Gregor ;
Hornung, Veit ;
Hopfner, Karl-Peter .
NATURE, 2013, 498 (7454) :332-+
[9]   Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases [J].
Clementz, Mark A. ;
Chen, Zhongbin ;
Banach, Bridget S. ;
Wang, Yanhua ;
Sun, Li ;
Ratia, Kiira ;
Baez-Santos, Yahira M. ;
Wang, Jie ;
Takayama, Jun ;
Ghosh, Arun K. ;
Li, Kui ;
Mesecar, Andrew D. ;
Baker, Susan C. .
JOURNAL OF VIROLOGY, 2010, 84 (09) :4619-4629
[10]   Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5 [J].
Cui, Shufang ;
Yu, Qiuya ;
Chu, Lei ;
Cui, Ye ;
Ding, Ming ;
Wang, Quanyi ;
Wang, Hongyun ;
Chen, Yu ;
Liu, Xing ;
Wang, Chen .
CELL REPORTS, 2020, 33 (10)