Production of nitric oxide, tumor necrosis factor-α and interleukin-6 by RAW264.7 macrophage cells treated with lactic acid bacteria isolated from kimchi

被引：18

作者：

Hur, HJ ^{[1
]}

Lee, KW ^{[1
]}

Lee, HJ ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Food Sci & Technol, Sch Agr Biotechnol, Seoul 151742, South Korea

来源：

BIOFACTORS | 2004年 / 21卷 / 1-4期

关键词：

kimchi lactic acid bacteria; immunopotentiating activity; nitric oxide; tumor necrosis factor-alpha; interleukin-6;

D O I：

10.1002/biof.552210124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study investigated immunopotentiating activities of lactic acid bacteria isolated from kimchi (KLAB) in vitro. A RAW264.7 macrophage cell line was stimulated with four strains of KLAB and two strains of bifidobacteria, and then the production of nitric oxide (NO) and cytokines-tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)-was determined. Lactobacillus plantarum, a lactic acid bacteria involved in the latent fermentation of kimchi, was the most effective for the generation of NO, TNF-alpha, and IL-6 in macrophage. All strains generated NO, while for the TNF-alpha and IL-6, only L. plantarum had significant activity. Our results indicate that L. plantarum plays an important role in the immunopotentiating activity of kimchi.

引用

页码：123 / 125

页数：3

共 5 条

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