Adhesion Force Studies of Nanofibers and Nanoparticles

被引:29
作者
Xing, Malcolm [2 ,5 ,6 ]
Zhong, Wen [1 ,4 ]
Xu, Xiuling [1 ]
Thomson, Douglas [3 ]
机构
[1] Univ Manitoba, Dept Text Sci, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Dept Mech Engn, Winnipeg, MB R3T 2N2, Canada
[3] Univ Manitoba, Dept Elect Engn, Winnipeg, MB R3T 2N2, Canada
[4] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3T 2N2, Canada
[5] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3T 2N2, Canada
[6] Manitoba Inst Child Hlth, Winnipeg, MB R3T 2N2, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
AFM; MICROSCOPE;
D O I
10.1021/la100443d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Surface adhesion between nanofibers and nanoparticles has attracted attention for potential biomedical applications, but the measurement has not been reported. Adhesion forces We re measured using a polystyrene (PS) nanoparticle attached to an atomic force microscopy (A FM) tip/probe. Electrospun PS nanofibers of different diameters were tapped with the probe to study the effect of fiber diameters on adhesion force. Both A FM experiments and numerical models suggest that the adhesion force increases with increased fiber diameters. Numerical models further demonstrated that local deformation of the fiber surface, including the flattening of surface asperities and the nanofiber wrapping around the particle during contact, may have a significant impact on the adhesion force. The adhesion forces are in the order of 100 nN, much smaller than the adhesion forces of the gecko foot hair, but much larger than that of the receptor-ligand pair, antibody-antigen pair, and single-stranded DNA from a substrate. Adhesion forces of nanofibers with roughness were predicted by numerical analysis. This study is expected to provide approaches and information useful in the design of nanomedicine and scaffold based on nanofibers for tissue engineering and regenerative medicine.
引用
收藏
页码:11809 / 11814
页数:6
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