Prion diseases

被引：26
作者：
Aguzzi, A
Weissmann, C
机构：
[1] Univ Zurich, Dept Pathol, Inst Neuropathol, CH-8006 Zurich, Switzerland
[2] Univ Zurich, Inst Mol Biol, CH-8006 Zurich, Switzerland
来源：
HAEMOPHILIA | 1998年 / 4卷 / 04期
关键词：
prions; bovine spongiform encephalopathy; transgenic mice; neuroinvasion;
D O I：
10.1046/j.1365-2516.1998.440619.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although the nature of the infectious agent causing prion diseases is still debated, several of its molecular characteristics have been clarified in remarkable detail. The transmissibility of bovine spongiform encephalopathy to humans dramatically highlights the need for research focused at interference with prion replication and spread, and at prevention of brain damage. Precondition to achieving these goals is a thorough understanding of prion biology, and in particular of its protein chemistry.
引用
收藏
页码：619 / 627
页数：9
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