Dendritic cells in tolerance induction for the treatment of autoimmune diseases

被引：19

作者：

Rescigno, Maria ^{[1
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 08期

关键词：

REGULATORY T-CELLS; INTESTINAL EPITHELIAL-CELLS; COLLAGEN-INDUCED ARTHRITIS; IN-VIVO; TGF-BETA; INDOLEAMINE 2,3-DIOXYGENASE; SUPPRESSOR ACTIVITY; RETINOIC-ACID; SEMI-MATURE; ANTIGEN;

D O I：

10.1002/eji.201040474

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases are characterized by the loss of tolerance toward self-antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a nonspecific fashion, which is inevitably accompanied by several side effects. Antigen-specific immunomodulation and patient-tailored therapies are likely to solve these issues and to elicit long-term protection against disease flares. This Viewpoint analyzes the potential use of DC for induction of antigen-specific tolerance in autoinunune disease settings.

引用

页码：2119 / 2123

页数：5

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