Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid

被引：27

作者：

Bellier, B ^{[1
]}

Da Nascimento, S ^{[1
]}

Meudal, H ^{[1
]}

Gincel, E ^{[1
]}

Roques, BP ^{[1
]}

Garbay, C ^{[1
]}

机构：

[1] UFR Sci Pharmaceut & Biol, CNRS URA D1500, INSERM U266, Dept Pharmacochim Mol & Struct, F-75270 Paris 06, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

cholecystokinin; peptoids; antagonists;

D O I：

10.1016/S0960-894X(98)00231-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1419 / 1424

页数：6

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