ERCC2/XPD Lys751Gln and Asp312Asn Gene Polymorphism and Lung Cancer Risk A Meta-Analysis Involving 22 Case-Control Studies

Introduction: Published data on the association between XPD Lys75/Gln and Asp312Asn gene polymorphism and lung cancel risk are inconclusive Methods: To derive a more precise estimation of the relationship, a meta-analysis was performed Results: A total of 22 studies including 15,507 subjects lot XPD Lys75/Gln genotype and 13,198 subjects for XPD Asp312Asn genotype were examined For XPD Lys751Gln genotype, significantly increased lung cancer risk was associated with two variant genotypes (CC versus AA odds ratio [OR] = I 26, 95% confidence interval [CI] = 1 12-1 42, p = 0 473 for heterogeneity. C allele earners versus AA OR = I 18, 95% Cl = 1 08-1 36,p = 0 732 for heterogeneity) When stratified by ethnicity, significantly increased risks were found among Caucasians but not in Asians For XPD Asp312Asn genotype, significantly increased lung cancer risk was associated with two variant genotypes (AA versus GO OR I 24, 95% Cl = I 09-1 42, p = 0 104 for heterogeneity, the A allele carriers versus GO OR = 135, 95% CI = 1 13-1 57,p = 0 219 for heterogeneity) When stratified analysis by ethnicity, significantly increased risks were found among Asians but not in Caucasians In the subgroup analyses by smoking status, there were no significant associations among the nonsmoker subgroup, however, significantly increased luny cancer risks were found in the smoking group Conclusion: This meta-analysis suggests that the XPD Lys751Gln and Asp312Asn gene polymorphisms ale associated with lung cancer risk, the C allele of XPD Lys751Gln genotype is an increased risk factor for developing lung cancer among Caucasians and in smokers, and the A allele of XPD 312 genotype is also an increased risk factor among Asians and in smokers