Development of a tandem time-of-flight mass spectrometer with an electrospray ionization ion source

被引：6

作者：

Nagao, Hirofumi ^{[1
]}

Shimma, Shuichi ^{[2
]}

Hayakawa, Shigeo ^{[3
]}

Awazu, Kunio ^{[4
]}

Toyoda, Michisato ^{[1
,2
,5
]}

机构：

[1] Osaka Univ, Renovat Ctr Instruments Sci Educ & Technol, Osaka 5600043, Japan

[2] Osaka Univ, Venture Business Lab, Ctr Adv Sci & Innovat, Suita, Osaka 5650871, Japan

[3] Osaka Prefecture Univ, Dept Chem, Grad Sch Sci, Naka Ku, Osaka 5998531, Japan

[4] Osaka Univ, Div Sustainable Energy & Environm Engn, Grad Sch Engn, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Dept Phys, Grad Sch Sci, Osaka 5600043, Japan

来源：

JOURNAL OF MASS SPECTROMETRY | 2010年 / 45卷 / 08期

关键词：

tandem time-of-flight mass spectrometer; ESI-TOF/quadTOF; multiply protonated peptide; high-energy CID; quadratic-field ion mirror; COLLISION-INDUCED DISSOCIATION; SEQUENCE IONS; CHARGE-STATE; PEPTIDES; PROTEINS; FRAGMENTATION; SPECTRA; PROTEOMICS; TOF/TOF; LIFT;

D O I：

10.1002/jms.1787

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new tandem time-of-flight mass spectrometer with an electrospray ionization ion source 'ESI-TOF/quadTOF' was designed and constructed to achieve the desired aim of structural elucidation via high-energy collision-induced dissociation (CID), and the simultaneous detection of all fragment ions. The instrument consists of an orthogonal acceleration-type ESI ion source, a linear TOF mass spectrometer, a collision cell, a quadratic-field ion mirror and a microchannel plate detector. High-energy CID spectra of doubly protonated angiotensin II and bradykinin were obtained. Several fragment ions such as a-, d-, v- and w-type ions, characteristic of high-energy CID, were clearly observed in these spectra. These high-energy CID fragment ions enabled confirmation of the complete sequence, including leucine-isoleucine determinations. It was demonstrated that high-energy CID of multiply protonated peptides could be achieved in the ESI-TOF/quadTOF. Copyright (c) 2010 John Wiley & Sons, Ltd.

引用

页码：937 / 943

页数：7

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