Results of a two-year pilot study of clinical outcome measures in collagen VI- and laminin alpha2-related congenital muscular dystrophies

被引：31

作者：

Meilleur, Katherine G. ^{[1
]}

Jain, Minal S. ^{[2
]}

Hynan, Linda S. ^{[3
,4
]}

Shieh, Ching-Yi ^{[5
]}

Kim, Eunice ^{[6
]}

Waite, Melissa ^{[2
]}

McGuire, Michelle ^{[7
]}

Fiorini, Courtney ^{[8
,9
,10
]}

Glanzman, Allan M. ^{[11
]}

Main, Marion ^{[12
,13
]}

Rose, Kristy ^{[14
]}

Duong, Tina ^{[15
]}

Bendixen, Roxanna ^{[16
]}

Linton, Melody M. ^{[1
]}

Arveson, Irene C. ^{[1
]}

Nichols, Carmel ^{[2
]}

Yang, Kelly ^{[17
]}

Fischbeck, Kenneth H. ^{[17
]}

Wagner, Kathryn R. ^{[8
,9
,10
]}

North, Kathryn ^{[14
]}

Mankodi, Ami ^{[17
]}

Grunseich, Christopher ^{[17
]}

Hartnett, Elizabeth J. ^{[17
]}

Smith, Michaele ^{[2
]}

Donkervoort, Sandra ^{[17
]}

Schindler, Alice ^{[17
]}

Kokkinis, Angela ^{[17
]}

Leach, Meganne ^{[15
,17
]}

Foley, A. Reghan ^{[12
,13
]}

Collins, James ^{[7
]}

Muntoni, Francesco ^{[12
,13
]}

Rutkowski, Anne ^{[6
,18
]}

Boennemann, Carsten G. ^{[17
]}

机构：

[1] NINR, NIH, Bethesda, MD 20814 USA

[2] NIH, Mark O Haeld Clin Res Ctr, Bethesda, MD 20892 USA

[3] Univ Texas Southwestern, Dept Clin Sci Biostat, Dallas, TX USA

[4] Univ Texas Southwestern, Dept Psychiat, Dallas, TX USA

[5] NIH, Bethesda, MD 20892 USA

[6] CureCMD, Los Angeles, CA USA

[7] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA

[8] Johns Hopkins Sch Med, Kennedy Krieger Inst, Baltimore, MD USA

[9] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA

[10] Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD USA

[11] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[12] UCL, Inst Child Hlth, MRC Ctr Neuromuscular Dis, Dubowitz Neuromuscular Ctr, London, England

[13] Great Ormond St Hosp Sick Children, London WC1N 3JH, England

[14] Childrens Hosp Westmead, Inst Neurosci & Muscle Res, Sydney, NSW, Australia

[15] Childrens Natl Med Ctr, Washington, DC 20010 USA

[16] Univ Pittsburgh, Pittsburgh, PA USA

[17] NINDS, NIH, Bethesda, MD 20892 USA

[18] Kaiser SCPMG, Los Angeles, CA USA

来源：

NEUROMUSCULAR DISORDERS | 2015年 / 25卷 / 01期

关键词：

Clinical outcome measures; Neuromuscular disease; Collagen VI related muscular dystrophy; Laminin alpha 2 related dystrophy; Motor function scales; FUNCTIONAL MOTOR SCALE; ACTIVITY LIMITATIONS; NATURAL-HISTORY; RELIABILITY; CHILDREN; RESPONSIVENESS; VALIDITY; QUALITY; ADULTS; MUSCLE;

D O I：

10.1016/j.nmd.2014.09.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Potential therapies are currently under development for two congenital muscular dystrophy (CMD) subtypes: collagen VI-related muscular dystrophy (COL6-RD) and laminin alpha 2-related dystrophy (LAMA2-RD). However, appropriate clinical outcome measures to be used in clinical trials have not been validated in CMDs. We conducted a two-year pilot study to evaluate feasibility, reliability, and validity of various outcome measures, particularly the Motor Function Measure 32, in 33 subjects with COL6-RD and LAMA2-RD. In the first year, outcome measures tested included: Motor Function Measure 32 (MFM32), forced vital capacity (FVC) percent predicted sitting, myometry, goniometry, 10-meter walk, Egen Klassification 2, and PedsQL(TM) Generic and Neuromuscular Cores. In the second year, we added the North Star Ambulatory Assessment (NSAA), Hammersmith Functional Motor Scale (HFMS), timed functional tests, Measure of Activity Limitations (ACTIVLIM), Quality of Upper Extremity Skills Test (QUEST), and Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue subscale. The MFM32 showed strong inter-rater (0.92) and internal consistency (0.96) reliabilities. Concurrent validity for the MFM32 was supported by large correlations (range 0.623-0.936) with the following: FVC, NSAA, HFMS, timed functional tests, ACTIVLIM, and QUEST. Significant correlations of the MFM32 were also found with select myometry measurements, mainly of the proximal extremities and domains of the PedsQL(TM) scales focusing on physical health and neuromuscular disease. Goniometry measurements were less reliable. The Motor Function Measure is reliable, and valid in the two specific subtypes of CMD evaluated, COL6-RD and LAMA2-RD. The NSAA is useful as a complementary outcome measure in ambulatory individuals. Preliminary concurrent validity of several other clinical outcome measures was also demonstrated for these subtypes. Published by Elsevier B.V.

引用

页码：43 / 54

页数：12

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