Plant-based vaccines against human hepatitis B virus

被引：4

作者：

Shchelkunov, Sergei N. ^{[1
]}

Shchelkunova, Galina A. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

EXPERT REVIEW OF VACCINES | 2010年 / 9卷 / 08期

关键词：

edible vaccine; hepatitis B virus; plant virus; protective antigen; transgenic plant; vaccine; SURFACE-ANTIGEN; ORAL IMMUNIZATION; TRANSGENIC PLANTS; EDIBLE VACCINE; IMMUNOGENICITY; EXPRESSION; PROTEIN; ANTIBODIES; PARTICLES; PLASTIDS;

D O I：

10.1586/ERV.10.67

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human hepatitis B virus (HBV) causes a communicable disease that spreads worldwide and has brought about considerable economic losses due to human mortality and morbidity. HBV fails to reproduce in both cell cultures and laboratory animals; however, it is known that excess virion surface protein named hepatitis B surface antigen (HBsAg) is produced during viral replication and circulates in the blood of carriers as noninfectious particles of 22-nm diameter. It had been shown that purified HBsAg particles induce an efficient systemic immune response after injection. Consequently, subunit HBV vaccines based on HBsAg synthesized in yeasts or mammalian cell culture are currently used. Taking into account that hepatitis B is a sexually transmitted disease, development of a mucosal HBV vaccine would be beneficial. In this article, we analyze the data on development of plant-based HBV vaccines.

引用

页码：947 / 955

页数：9

共 49 条

[31] Immunogenicity of recombinant hepatitis B virus surface antigen fused with preS1 epitopes expressed in rice seeds
Qian, Bingjun
Shen, Huifeng
Liang, Wanqi
Guo, Xiumei
Zhang, Chengmei
Wang, Yuan
Li, Guangdi
Wu, Aibo
Cao, Kaiming
Zhang, Dabing
[J]. TRANSGENIC RESEARCH, 2008, 17 (04) : 621 - 631
[32] Safety and immunogenicity of a novel mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens in children
Raz, R
Dagan, R
Gallil, A
Brill, G
Kassis, I
Koren, R
[J]. VACCINE, 1996, 14 (03) : 207 - 211
[33] Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine
Rendi-Wagner, P
Shouval, D
Genton, B
Lurie, Y
Rümke, H
Boland, G
Cerny, A
Heim, M
Bach, D
Schroeder, M
Kollaritsch, H
[J]. VACCINE, 2006, 24 (15) : 2781 - 2789
[34] Production of hepatitis B surface antigen in transgenic plants for oral immunization
Richter, LJ
Thanavala, Y
Arntzen, CJ
Mason, HS
[J]. NATURE BIOTECHNOLOGY, 2000, 18 (11) : 1167 - 1171
[35] Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit
Ruf, S
Hermann, M
Berger, IJ
Carrer, H
Bock, R
[J]. NATURE BIOTECHNOLOGY, 2001, 19 (09) : 870 - 875
[36] The obtaining of transgenic tomato plant producing chimerical proteins TBI-HBsAg
Shchelkunov S.N.
Salyaev R.K.
Rekoslavskaya N.I.
Ryzhova T.S.
Pozdnyakov S.G.
Sumtsova V.M.
Pakova N.V.
Mishutina U.O.
Kopytina T.V.
Hammond R.
[J]. Doklady Biochemistry and Biophysics, 2004, 396 (1-6) : 139 - 142
[37] Study of immunogenic properties of the candidate edible vaccine against human immunodeficiency and hepatitis B viruses based on transgenic tomato fruits
Shchelkunov S.N.
Salyaev R.K.
Rekoslavskaya N.I.
Pozdnyakov S.G.
Nesterov A.E.
Sumtsova V.M.
Pakova N.V.
Mishutina U.O.
Kopytina T.V.
Hammond R.
[J]. Doklady Biochemistry and Biophysics, 2005, 401 (1-6) : 167 - 169
[38] [Щелкунов С.Н. Shchelkunov S.N.], 2009, [Российский иммунологический журнал, Russian Journal of Immunology, Rossiiskii immunologicheskii zhurnal], V3, P235
[39] Immunogenicity of a novel, bivalent, plant-based oral vaccine against hepatitis B and human immunodeficiency viruses
Shchelkunov, Sergei N.
Salyaev, Rurik K.
Pozdnyakov, Sergei G.
Rekoslavskaya, Natalia I.
Nesterov, Andrei E.
Ryzhova, Tatiana S.
Sumtsova, Valentina M.
Pakova, Natalia V.
Mishutina, Uliana O.
Kopytina, Tatiana V.
Hammond, Rosemarie W.
[J]. BIOTECHNOLOGY LETTERS, 2006, 28 (13) : 959 - 967
[40] SHCHELKUNOV SN, 2004, VESTN ROS AKAD MED, V11, P50

← 1 2 3 4 5 →