Decreased fasting serum glucogenic amino acids with a higher compared to normal protein diet during energy restriction in women: a randomized controlled trial

被引:56
作者
Ogilvie, A. R. [1 ,2 ]
Watford, M. [1 ,2 ]
Wu, G. [3 ]
Sukumar, D. [4 ]
Kwon, J. [1 ,2 ]
Shapses, S. A. [1 ,2 ,5 ]
机构
[1] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA
[2] NJ Inst Food Hlth & Nutr, New Brunswick, NJ 08901 USA
[3] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA
[4] Drexel Univ, Dept Nutr Sci, Philadelphia, PA 19104 USA
[5] Rutgers RWJ Med Sch, Dept Med, New Brunswick, NJ 08901 USA
关键词
Diet; Glucogenic amino acids; Lysine; Protein; Weight loss; PLASMA-CONCENTRATIONS; CALORIC RESTRICTION; METABOLISM; GLUTAMATE;
D O I
10.1007/s00726-021-03053-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dietary protein alters circulating amino acid (AAs) levels and higher protein intake (HP) is one means of losing weight. We examined 34 overweight and obese women (57 +/- 4 years) during 6 months of energy restriction (7.3 +/- 3.8% weight loss) divided into groups consuming either normal protein (NP; 18.6 energy% protein) or HP (24.3 energy% protein). There was a reduction in fasting serum glucogenic AAs (p = 0.015) that also associated with greater weight loss (p < 0.05) in the HP group, but not in the NP group. These findings have implications for nutrient prioritization during energy restriction.
引用
收藏
页码:1467 / 1472
页数:6
相关论文
共 30 条
[1]   Enzymes involved in branched-chain amino acid metabolism in humans [J].
Adeva-Andany, Maria M. ;
Lopez-Maside, Laura ;
Donapetry-Garcia, Cristobal ;
Fernandez-Fernandez, Carlos ;
Sixto-Leal, Cristina .
AMINO ACIDS, 2017, 49 (06) :1005-1028
[2]  
ADIBI SA, 1971, AM J PHYSIOL, V221, P829
[3]   AMINO-ACID AND GLUCOSE-METABOLISM IN THE POSTABSORPTIVE STATE AND FOLLOWING AMINO-ACID INGESTION IN THE DOG [J].
BARRETT, EJ ;
GUSBERG, R ;
FERRANNINI, E ;
TEPLER, J ;
FELIG, P ;
JACOB, R ;
SMITH, D ;
DEFRONZO, RA .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1986, 35 (08) :709-717
[4]   The effects of carbohydrate variation in isocaloric diets on glycogenolysis and gluconeogenesis in healthy men [J].
Bisschop, PH ;
Arias, AMP ;
Ackermans, MT ;
Endert, E ;
Pijl, H ;
Kuipers, F ;
Meijer, AJ ;
Sauerwein, HP ;
Romijn, JA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (05) :1963-1967
[5]   Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition [J].
Encarnacion Palomo-Buitrago, Maria ;
Sabater-Masdeu, Monica ;
Maria Moreno-Navarrete, Jose ;
Caballano-Infantes, Estefania ;
Arnoriaga-Rodriguez, Maria ;
Coll, Claudia ;
Ramio, Lluis ;
Palomino-Schatzlein, Martina ;
Gutierrez-Carcedo, Patricia ;
Perez-Brocal, Vicente ;
Simo, Rafael ;
Moya, Andres ;
Ricart, Wifredo ;
Raul Herance, Jose ;
Manuel Fernandez-Real, Jose .
ACTA DIABETOLOGICA, 2019, 56 (05) :569-579
[6]   Inverse relationship between protein intake and plasma free amino acids in healthy men at physical exercise [J].
Forslund, AH ;
Hambræus, L ;
Van Beurden, H ;
Holmbäck, U ;
El-Khoury, AE ;
Hjorth, G ;
Olsson, R ;
Stridsberg, M ;
Wide, L ;
Åkerfeldt, T ;
Regan, M ;
Young, VR .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 278 (05) :E857-E867
[7]   Very Low Carbohydrate Diet Significantly Alters the Serum Metabolic Profiles in Obese Subjects [J].
Gu, Yunjuan ;
Zhao, Aihua ;
Huang, Fengjie ;
Zhang, Yinan ;
Liu, Jiajian ;
Wang, Congrong ;
Jia, Wei ;
Xie, Guoxiang ;
Jia, Weiping .
JOURNAL OF PROTEOME RESEARCH, 2013, 12 (12) :5801-5811
[8]   Composition of polyamines and amino acids in plant-source foods for human consumption [J].
Hou, Yongqing ;
He, Wenliang ;
Hu, Shengdi ;
Wu, Guoyao .
AMINO ACIDS, 2019, 51 (08) :1153-1165
[9]  
Lashinger LM, 2016, CANCER METAB, V4, DOI 10.1186/s40170-016-0158-4
[10]   High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: Case-cohort study within the PREDIMED trial [J].
Liu, Xiaoran ;
Zheng, Yan ;
Guasch-Ferre, Marta ;
Ruiz-Canela, Miguel ;
Toledo, Estefania ;
Clish, Clary ;
Liang, Liming ;
Razquin, Cristina ;
Corella, Dolores ;
Estruch, Ramon ;
Fito, Montserrat ;
Gomez-Gracia, Enrique ;
Aros, Fernando ;
Ros, Emilio ;
Lapetra, Jose ;
Fiol, Miquel ;
Serra-Majem, Lluis ;
Papandreou, Christopher ;
Martinez-Gonzalez, Miguel A. ;
Hu, Frank B. ;
Salas-Salvado, Jordi .
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2019, 29 (10) :1040-1049