THE EFFECTS OF PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE IN RENAL ISCHEMIA/REPERFUSION

被引：10
作者：
Laszlo, Eszter [1 ]
Kiss, P. [1 ]
Horvath, Gabriela [1 ]
Szakaly, P. [1 ]
Tamas, Andrea [1 ]
Reglodi, Dora [1 ]
机构：
[1] Univ Pecs, Dept Surg, Pecs, Hungary
来源：
ACTA BIOLOGICA HUNGARICA | 2014年 / 65卷 / 04期
关键词：
Kidney; ischemia/reperfusion; PACAP; renoprotection; VASOACTIVE INTESTINAL POLYPEPTIDE; IN-VITRO; ISCHEMIA-REPERFUSION; MULTIPLE-MYELOMA; INCREASED SENSITIVITY; OXIDATIVE STRESS; GENE-EXPRESSION; MICE DEFICIENT; RAT-BRAIN; PACAP;
D O I：
10.1556/ABiol.65.2014.4.1
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycin-and cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusion-induced kidney injury and gives a brief summary about the results published in this area.
引用
收藏
页码：369 / 378
页数：10
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