Clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype

被引：25

作者：

Song, Jae-Hoon ^{[1
,2
]}

Ko, Kwan Soo ^{[2
,3
]}

Suh, Ji Yoeun

Oh, Won Sup ^{[1
]}

Kang, Cheol-In ^{[1
]}

Chung, Doo Ryeon ^{[1
]}

Peck, Kyong Ran ^{[1
]}

Lee, Nam Yong ^{[1
]}

Lee, Wee Gyo ^{[4
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis,Lab Med, Seoul, South Korea

[2] Asian Pacific Res Fdn Infect Dis ARFID, Seoul, South Korea

[3] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon, South Korea

[4] Ajou Univ, Sch Med, Dept Lab Med, Suwon, South Korea

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2008年 / 61卷 / 04期

关键词：

vancomycin-resistant enterococci; teicoplanin; VanD-vanA;

D O I：

10.1093/jac/dkn025

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: To investigate the clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype (VanD-vanA VRE). Methods: We tested in vitro and in vivo efficacies of teicoplanin against VanD-vanA VRE strains. Change in teicoplanin MICs was monitored during incubation with teicoplanin. In vitro and in vivo time-kill assay and survival analysis using a mouse peritonitis model were performed. Results: Teicoplanin MICs of VanD-vanA VRE strains increased to 128 mg/L within 48 h when they were cultured with 120 mg/L teicoplanin. In vitro and in vivo time-kill assay showed that VanD-vanA VRE strains were not eliminated by 120 mg/L teicoplanin in contrast to vancomycin-susceptible E. faecium and VanD-vanB strains. The survival rate of mice infected with VanD-vanA VRE strains treated with teicoplanin was comparable with that of untreated mice. Conclusion: Data suggest that teicoplanin would fail in the treatment of VanD type VRE infections if the strains contained the vanA gene, which cannot be detected in the clinical microbiology laboratory.

引用

页码：838 / 844

页数：7

共 25 条

[11] Distribution of insertion sequences associated with Tn1546-like elements among Enterococcus faecium isolates from patients in Korea [J].