MYC and Metastasis

被引：142

作者：

Wolfer, Anita ^{[1
,2
]}

Ramaswamy, Sridhar ^{[1
,2
,3
,4
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Broad Inst, Cambridge, MA USA

[4] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

CANCER RESEARCH | 2011年 / 71卷 / 06期

关键词：

TO-MESENCHYMAL TRANSITION; BREAST-CANCER; COLORECTAL-CANCER; GENE-EXPRESSION; STEM-CELLS; AMPLIFICATION; REPRESSION; OVEREXPRESSION; TRANSFORMATION; PROLIFERATION;

D O I：

10.1158/0008-5472.CAN-10-3776

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of controversy. We recently found that many prognostic signatures reflect the activity of the MYC oncogene, which in turn regulates tumor metastasis through specific effects on cancer cell invasion and migration. These findings offer a general framework for understanding the molecular basis of clinically prognostic transcriptional signatures and suggest potentially new avenues for studying metastasis. Cancer Res; 71(6); 2034-7. (C) 2011 AACR.

引用

页码：2034 / 2037

页数：4

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