Evidence for suppression of electroacupuncture on spinal glial activation and behavioral hypersensitivity in a rat model of monoarthritis

被引：77
作者：
Sun, S. [1 ,2 ]
Cao, H. [1 ,2 ]
Han, M. [1 ,2 ]
Li, T. T. [1 ,2 ]
Zhao, Z. Q. [1 ,2 ]
Zhang, Y. Q. [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Med Coll, Inst Neurobiol, Inst Brain Sci, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China
来源：
BRAIN RESEARCH BULLETIN | 2008年 / 75卷 / 01期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
astrocytes; microglia; electroacupuncture; monoarthritis; hypersensitivity; spinal cord;
D O I：
10.1016/j.brainresbull.2007.07.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Our previous study demonstrated that single intrathecal (i.t.) application of fluorocitrate, a glial metabolic inhibitor, synergized electroacupuncture (EA) antagonizing behavioral hypersensitivity in complete Freund's adjuvant (CFA)-induced monoarthritic rat. To further investigate the relationship between spinal glial activation and EA analgesia, the present study examined the effects of multiple EA on spinal glial activation evoked by monoarthritis (MA). The results showed that (1) unilateral intra-articular injection of CFA produced a robust glial activation on the spinal cord, which was associated with the development and maintenance of behavioral hypersensitivity; (2) multiple EA stimulation of ipsilateral "Huantiao" (GB30) and "Yanglingquan" (GB34) acupoints or i.t. injection of fluorocitrate (1 nmol) significantly suppressed spinal glial activation; (3) inhibitory effects of EA on spinal glial activation and behavioral hypersensitivity were significantly enhanced when EA combined with fluorocitrate, indicating that disruption of glial function may potentiate EA analgesia in inflammatory pain states. These data suggested that analgesic effects of EA might be associated with its counter-regulation to spinal glial activation, and thereby provide a potential strategy for the treatment of arthritis. (C) 2007 Elsevier Inc. All rights reserved.
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收藏
页码：83 / 93
页数：11
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