Early diagnosis of aspergillosis in asthmatic and rheumatoid arthritis patients by Aspergillus galactomannan antigen assay: a case-control study in Karbala providence

被引:2
作者
Al-Janabi, Ali Abdul Hussein S. [1 ]
Ali, Roaa Noori [1 ]
机构
[1] Univ Karbala, Dept Microbiol, Coll Med, Karbala, Iraq
关键词
Aspergillosis; asthma; rheumatoid arthritis; galactomannan; ELISA; ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; PULMONARY ASPERGILLOSIS; CLINICAL-MANIFESTATIONS; INVASIVE ASPERGILLOSIS; SERUM;
D O I
10.1080/02770903.2021.1996601
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Objective Aspergillosis is an opportunistic systemic infection caused by members of Aspergillus spp. in various parts of the human body. Chronic diseases such as rheumatoid arthritis (RA) and asthma may encourage the development of aspergillosis under specific conditions. Thus, aspergillosis was investigated in patients with RA and asthma based on detection of galactomannan antigen. Methods A case-control study was performed to involve 184 subjects, distributing in four groups: 55 patients with RA, 54 with asthma, 27 with both RA and asthma, and 48 healthy individuals. Serum was collected from involved subjects for detection of human Aspergillus galactomannan by ELISA. The optical density index (ODI) at cutoff Results Aspergillosis was more frequently diagnosed in females with RA and both RA and asthma in opposite to the males. It also was found in most common in middle-aged subjects. There was no significant difference in measurement of GM between all patient groups and healthy individuals. Conclusion Aspergillosis can develop in either immunocompetent or immunocompromised individuals. Patients with either RA or RA and asthma are more susceptible to acquired aspergillosis than those with only one disease. Application of GM for diagnosis of aspergillosis may show a nonsignificant results when it uses alone and needs other investigation tests.
引用
收藏
页码:2276 / 2282
页数:7
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