Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq. var. formosana

被引：19

作者：

Chan, Hsiu-Hui ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Su, Chung-Ren ^{[1
]}

Reddy, Mopur Vijaya Bhaskar ^{[1
]}

Wu, Tian-Shung ^{[1
,3
,4
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] China Med Univ, Dept Pharm, Taichung 404, Taiwan

[4] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

来源：

PHYTOMEDICINE | 2011年 / 18卷 / 2-3期

关键词：

Salvia nipponica Miq. var. formosana; Lamiaceae; Superoxide anion generation; Elastase release; Cholinesterase; DPPH; EXTRACT;

D O I：

10.1016/j.phymed.2010.06.017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Reactive oxygen species and granule proteases produced by neutrophils contribute to the pathogenesis of inflammatory diseases. The extracts of the roots and the leaves of Salvia nipponica var. formosana were showed potent inhibitory effects on superoxide anion production in fMLP/CB-activated human neutrophils as well as other anti-inflammatory effects, and led to the isolation of 25 compounds. Among them, compounds 8, 12, 13, 14, 15, 17 and 20 were exhibited more potent inhibitory effect on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB. Moreover, those isolated compounds also showed significant anticholinesterase and antioxidative activities. To the best of our knowledge, this is the first report of phytochemical and biological activity study on S. nipponica var. formosana. Crown Copyright (C) 2010 Published by Elsevier GmbH. All rights reserved.

引用

页码：148 / 150

页数：3

共 11 条

[1] Essential oils of Salvia bracteata and Salvia rubifolia from Lebanon: Chemical composition, antimicrobial activity and inhibitory effect on human melanoma cells [J].