Constituents from the Seeds of Sophora Alopecuroides L.

被引：22

作者：

Rong, Zi-Jian ^{[1
]}

Hu, Gao-Sheng ^{[1
]}

Lin, Shi-Yi ^{[2
]}

Yan, Ting ^{[1
]}

Li, Na ^{[1
]}

Zhao, Yue ^{[1
]}

Jia, Jing-Ming ^{[1
]}

Wang, An-Hua ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Coll Pharm, Shenyang 110016, Peoples R China

来源：

MOLECULES | 2020年 / 25卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

S. alopecuroides L; isoflavone glucosides; structure elucidation; cytotoxicity; FLAVONOIDS; FLAVESCENS; ROOTS;

D O I：

10.3390/molecules25020411

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new isoflavone glucosides, kudonol A-C (1-3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4-5) and five known compounds, (-)-maackiain (6), neoliquiritin (7), methyl 4-coumarate (8), methyl ferulate (9) and (+)-wikstromol (10), were isolated from an extract of dried seeds of the traditional Chinese medicinal plant Sophora alopecuroides L. Their structures were established by NMR and HRESIMS data analyses. The monosaccharide part's configuration of isoflavone glucosides was confirmed by acid hydrolysis and analyzed by a JAsco OR-4090 chiral detector, comparing it to standard substance D-glucose. The cytotoxicity effects against HeLa, Hep3B, MCF-7 and H1299 cells were tested by CCK-8 assay.

引用

页数：8

共 15 条

[1]

Chen Wen, 2012, Zhongguo Zhong Yao Za Zhi, V37, P806

[2] Solvent effect in 1H NMR spectra of 3′-hydroxy-4′-methoxy isoflavonoids from Astragalus membranaceus var. mongholicus [J].

Du, Xingang ;

Bai, Yanjing ;

Liang, Hong ;

Wang, Zhiying ;

Zhao, Yuying ;

Zhang, Qingying ;

Huang, Luqi .

MAGNETIC RESONANCE IN CHEMISTRY, 2006, 44 (07) :708-712

[3] A New Alkaloid from the Seeds of Sophora alopecuroides L. [J].

Gao, Hong-Ying ;

Li, Guo-Yu ;

Wang, Jin-Hui .

HELVETICA CHIMICA ACTA, 2012, 95 (07) :1108-1113

[4] Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor [J].

Hillerns, PI ;

Wink, M .

PLANTA MEDICA, 2005, 71 (11) :1065-1068

[5] Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica [J].

Hu, K ;

Kobayashi, H ;

Dong, A ;

Iwasaki, S ;

Yao, XS .

PLANTA MEDICA, 2000, 66 (06) :564-567

[6] Traditional uses, phytochemistry, and pharmacological properties of Sophora alopecuroides L [J].

Huang, Yan-Xia ;

Wang, Ge ;

Zhu, Jin-Shui ;

Zhang, Rui ;

Zhang, Jing .

EUROPEAN JOURNAL OF INFLAMMATION, 2016, 14 (02) :128-132

[7] Neolignan glycosides from Symplocos caudata [J].

Huo, Changhong ;

Liang, Hong ;

Zhao, Yuying ;

Wang, Bin ;

Zhang, Qingying .

PHYTOCHEMISTRY, 2008, 69 (03) :788-795

[8] Antifungal activity of cinnamic acid and benzoic acid esters against Candida albicans strains [J].

Lima, Tamires C. ;

Ferreira, Alana R. ;

Silva, Daniele F. ;

Lima, Edeltrudes O. ;

de Sousa, Damiao P. .

NATURAL PRODUCT RESEARCH, 2018, 32 (05) :572-575

[9] Flavonoids from preparation of traditional Chinese medicines named Sini-Tang [J].

Liu, HX ;

Lin, WH ;

Wang, XL ;

Yang, JS .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (02) :139-143

[10] Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa [J].

Raksat, Achara ;

Maneerat, Wisanu ;

Andersen, Raymond J. ;

Pyne, Stephen G. ;

Laphookhieo, Surat .

JOURNAL OF NATURAL PRODUCTS, 2018, 81 (08) :1835-1840

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