Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation of Chronic Granulomatous Disease

被引：15

作者：

Oshrine, Benjamin ^{[1
]}

Morsheimer, Megan ^{[2
]}

Heimall, Jennifer ^{[2
]}

Bunin, Nancy ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Immunol, Philadelphia, PA 19104 USA

来源：

PEDIATRIC BLOOD & CANCER | 2015年 / 62卷 / 02期

关键词：

chronic granulomatous disease; hematopoietic cell transplantation; primary immunodeficiency; reduced-intensity conditioning; UNRELATED DONOR; SURVIVAL;

D O I：

10.1002/pbc.25225

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematopoietic cell transplantation (HCT) is the only available curative therapy for chronic granulomatous disease (CGD), but its use is limited by transplant-related mortality (TRM) in patients who often come to transplant with existing infections or organ dysfunction. Reduction in the intensity of the preparative regimen mitigates these risks, but increases the potential for mixed donor-recipient chimerism (MC) that may progress to graft loss. Recently a busulfan-based reduced-intensity conditioning (RIC) regimen has been described with excellent survival and little MC. We report our experience with a similar RIC regimen at our institution, demonstrating problems with donor chimerism and graft loss. Pediatr Blood Cancer 2015;62:359-361. (C) 2014 Wiley Periodicals, Inc.

引用

页码：359 / 361

页数：3

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