Ceramide-enriched microdomains in planar membranes

被引：20

作者：

Zou, Shan ^{[1
]}

Johnston, Linda J. ^{[1
]}

机构：

[1] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada

来源：

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2010年 / 15卷 / 06期

关键词：

Ceramide; Monolayers; Supported bilayers; Microdomains; Sphingomyelinase; LIQUID-ORDERED DOMAINS; SPHINGOMYELINASE ACTIVITY; PHASE COEXISTENCE; NUCLEATION RATES; MODEL MEMBRANES; COMBINED AFM; LIPID RAFTS; CHOLESTEROL; CONVERSION; MIXTURES;

D O I：

10.1016/j.cocis.2010.06.003

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Ceramide has a large effect on the properties of biological membranes increasing lipid order and promoting lateral phase separation and plays an important role in cell signaling This review provides an overview of recent studies of the effects of direct ceramide incorporation and enzymatic ceramide generation on planar supported membranes including lipid monolayers and supported lipid Mayers Recent studies have focused on understanding the nucleation growth and morphology of ceramide gel domains characterizing the properties of ceramide-rich membrane phases and investigating the effects of ceramide on phase-separated membranes with co-existing liquid-ordered and fluid phases as models for cellular membranes Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved

引用

页码：489 / 498

页数：10

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