cis -Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice

被引：15

作者：

de Oliveira, Diego Pinto ^{[1
]}

Garcia, Eliana de Faria ^{[1
]}

de Oliveira, Mariana Assiria ^{[1
]}

Candido, Luiza C. M. ^{[2
]}

Coelho, Fernanda M. ^{[2
]}

Costa, Vivian Vasconcelos ^{[2
]}

Batista, Nathalia Vieira ^{[3
]}

Queiroz-Junior, Celso Martins ^{[3
]}

Brito, Larissa Froede ^{[4
]}

Sousa, Lirlandia Pires ^{[4
]}

Souza, Daniele G. ^{[2
]}

Amaral, Flavio Almeida ^{[3
]}

de Padua, Rodrigo Maia ^{[1
]}

Teixeira, Mauro Martins ^{[3
]}

Braga, Fernao Castro ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Pharm, Dept Pharmaceut Prod, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Fac Pharm, Dept Clin & Toxicol Anal, Belo Horizonte, MG, Brazil

来源：

PLANTA MEDICA | 2022年 / 88卷 / 13期

关键词：

cis-aconitic acid; rheumatoid arthritis; gout; complete Freund's adjuvant; Echinodorus grandiflorus; Alismataceae; NF kappa B; RHEUMATOID-ARTHRITIS; TNF-ALPHA; INFLAMMATION; NEUTROPHILS; HYPERNOCICEPTION; FRACTION; EXTRACT; MODEL;

D O I：

10.1055/a-1676-4371

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

cis-Aconitic acid is a constituent from the leaves of Echinodorus grandiflorus, amedicinal plant traditionally used in Brazil to treat inflammatory conditions, including arthritic diseases. The present study aimed to investigate the anti-arthritic effect of cis-aconitic acid in murine models of antigen-induced arthritis and monosodium urate-induced gout. The possible underlying mechanisms of action was evaluated in THP-1 macrophages. Oral treatment with cis-aconitic acid (10, 30, and 90mg/kg) reduced leukocyte accumulation in the joint cavity and C-X-C motif chemokine ligand 1 and IL-1 beta levels in periarticular tissue. cis-Aconitic acid treatment reduced joint inflammation in tissue sections of antigen-induced arthritis mice and these effects were associated with decreased mechanical hypernociception. Administration of cis-aconitic acid (30mg/kg p. o.) also reduced leukocyte accumulation in the joint cavity after the injection of monosodium urate crystals. cis-Aconitic acid reduced in vitro the release of TNF-a and phosphorylation of I.Ba in lipopolysaccharide-stimulated THP-1 macrophages, suggesting that inhibition of nuclear factor kappa B activation was an underlying mechanism of cis-aconitic acid-induced anti-inflammatory effects. In conclusion, cis-aconitic acid has significant anti-inflammatory effects in antigen-induced arthritis and monosodium urate-induced arthritis in mice, suggesting its potential for the treatment of inflammatory diseases of the joint in humans. Additionally, our findings suggest that this compound may contribute to the anti-inflammatory effect previously reported for E. grandiflorus extracts.

引用

页码：1123 / 1131

页数：9

共 45 条

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