Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids

被引:117
作者
Astarita, Giuseppe [1 ,2 ]
Kendall, Alexandra C. [3 ]
Dennis, Edward A. [4 ,5 ]
Nicolaou, Anna [3 ]
机构
[1] Waters Corp, Milford, MA USA
[2] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA
[3] Univ Manchester, Fac Med & Human Sci, Manchester Pharm Sch, Manchester M13 9PT, Lancs, England
[4] Univ Calif San Diego, Dept Chem Biochem, La Jolla, CA 92093 USA
[5] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2015年 / 1851卷 / 04期
基金
美国国家卫生研究院; 英国惠康基金;
关键词
PUFA; polyunsaturated fatty acid; Eicosanoid; Prostaglandin; Mass spectrometry; Lipidomics; Lipid mediator; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; BIOACTIVE OXIDIZED PHOSPHOLIPIDS; ARACHIDONIC-ACID; DOCOSAHEXAENOIC ACID; DIPOLYUNSATURATED PHOSPHATIDYLCHOLINES; SIMULTANEOUS QUANTIFICATION; ESTERIFIED EICOSANOIDS; QUANTITATIVE-ANALYSIS; CHOLESTERYL ESTERS;
D O I
10.1016/j.bbalip.2014.11.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidation of polyunsaturated fatty acids (PUFA) through enzymatic or non-enzymatic free radical-mediated reactions can yield an array of lipid metabolites including eicosanoids, octadecanoids, docosanoids and related species. In mammals, these oxygenated PUFA mediators play prominent roles in the physiological and pathological regulation of many key biological processes in the cardiovascular, renal, reproductive and other systems including their pivotal contribution to inflammation. Mass spectrometry-based technology platforms have revolutionized our ability to analyze the complex mixture of lipid mediators found in biological samples, with increased numbers of metabolites that can be simultaneously quantified from a single sample in few analytical steps. The recent development of high-sensitivity and high-throughput analytical tools for lipid mediators affords a broader view of these oxygenated PUFA species, and facilitates research into their role in health and disease. In this review, we illustrate current analytical approaches for a high-throughput lipidomic analysis of eicosanoids and related mediators in biological samples. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance." (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:456 / 468
页数:13
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