Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw

被引：74

作者：

Gentilli, M

Mazoit, JX ^{[1
]}

Bouaziz, H

Fletcher, D

Casper, RF

Benhamou, D

Savouret, JF

机构：

[1] Univ Paris Sud, Fac Med Kremlin Bicetre, Lab Anesthesie, UPRES EA392, F-94276 Le Kremlin Bicetre, France

[2] Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[3] Hop Bicetre, INSERM, U135, Le Kremlin Bicetre, France

来源：

LIFE SCIENCES | 2001年 / 68卷 / 11期

关键词：

pain; inflammation; cyclooxygenase; carrageenan;

D O I：

10.1016/S0024-3205(00)01018-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat. Pretreatment with resveratrol did not reverse swelling and edema, but reversed the hyperalgesia induced by local tissue injury provoked by carrageenan. This reversal, occurring at resveratrol concentrations as low as 2 mg/kg, lasted for at least 48 hours. The link with COX2 activity inhibition and COX2 gene transcription, as well as a potential AhR inhibitory effect, remain to be established. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1317 / 1321

页数：5

共 9 条

[1]

Casper RF, 1999, MOL PHARMACOL, V56, P784

[2] Influence of timing of administration on the analgesic effect of bupivacaine infiltration in carrageenin-injected rats [J].