Multiple system atrophy

被引：2
作者：
Klempir, J. [1 ,2 ,3 ,4 ]
Bartosova, T. [1 ,2 ,3 ]
机构：
[1] 1 LF UK & VFN Praze, Neurol Klin, Prague, Czech Republic
[2] 1 LF UK & VFN Praz, Ctr Klin Neuroved, Prague, Czech Republic
[3] 1 LF UK Praze, Anatom Ustav, Prague, Czech Republic
[4] Evropska Referencni Sit vzacna Neurol onemocneni, Prague, Czech Republic
来源：
CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE | 2019年 / 82卷 / 04期
关键词：
multiple system atrophy; atypical parkinsonian syndrome; alpha synuclein; REM sleep behavioral disorders; autonomic dysfunction; orthostatic hypotension; inspiratory stridor; PROGRESSIVE SUPRANUCLEAR PALSY; PURE AUTONOMIC FAILURE; PARKINSONS-DISEASE; NATURAL-HISTORY; TRANSCRANIAL SONOGRAPHY; WATER DRINKING; DIAGNOSIS; ASSOCIATION; AUTOPSY; POLYMORPHISMS;
D O I：
10.14735/amcsnn2019370
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Multiple system atrophy (MSA) is relatively rare neurodegenerative disease with fatal prognosis affecting middle-aged and elderly individuals. There is combination of several motor and non-motor symptoms in MSA. Causal treatment does not exist and symptomatic treatment effect is unsatisfactory. The article briefly discusses genetics and pathophysiology of MSA with special focus on the clinical picture, practical aspects of diagnostics and current therapeutic options of MSA in the Czech Republic.
引用
收藏
页码：370 / 380
页数：11
相关论文
共 76 条
[1]   Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients [J].
Anderson, Tim ;
Luxon, Linda ;
Quinn, Niall ;
Daniel, Susan ;
Marsden, C. David ;
Bronstein, Adolfo .
MOVEMENT DISORDERS, 2008, 23 (07) :977-984
[2]   Striatal deformities of the hand and foot in Parkinson's disease [J].
Ashour, R ;
Tintner, R ;
Jankovic, J .
LANCET NEUROLOGY, 2005, 4 (07) :423-431
[3]   Diffusion-weighted MRI distinguishes Parkinson disease from the parkinsonian variant of multiple system atrophy: A systematic review and meta-analysis [J].
Bajaj, Sweta ;
Krismer, Florian ;
Palma, Jose-Alberto ;
Wenning, Gregor K. ;
Kaufmann, Horacio ;
Poewe, Werner ;
Seppi, Klaus .
PLOS ONE, 2017, 12 (12)
[4]   Young-Onset Multiple System Atrophy: Clinical and Pathological Features [J].
Batla, Amit ;
De Pablo-Fernandez, Eduardo ;
Erro, Roberto ;
Reich, Martin ;
Calandra-Buonaura, Giovanna ;
Barbosa, Pedro ;
Balint, Bettina ;
Ling, Helen ;
Islam, Saiful ;
Cortelli, Pietro ;
Volkmann, Jens ;
Quinn, Niall ;
Holton, Janice L. ;
Warner, Thomas T. ;
Bhatia, Kailash P. .
MOVEMENT DISORDERS, 2018, 33 (07) :1099-1107
[5]   Markedly asymmetric presentation in multiple system atrophy [J].
Batla, Amit ;
Stamelou, Maria ;
Mensikova, Katerina ;
Kaiserova, Michaela ;
Tuckova, Lucie ;
Kanovsky, Petr ;
Quinn, Niall ;
Bhatia, Kailash P. .
PARKINSONISM & RELATED DISORDERS, 2013, 19 (10) :901-905
[6]   Brainstem in multiple system atrophy: Clinicopathological correlations [J].
Eduardo E. Benarroch .
Cellular and Molecular Neurobiology, 2003, 23 (4-5) :519-526
[7]   TRANSCRANIAL SONOGRAPHY FOR THE DISCRIMINATION OF IDIOPATHIC PARKINSON'S DISEASE FROM THE ATYPICAL PARKINSONIAN SYNDROMES [J].
Bouwmans, Angela E. P. ;
Vlaar, Annemarie M. M. ;
Srulijes, Karin ;
Mess, Werner H. ;
Weber, W. E. J. .
TRANSCRANIAL SONOGRAPHY IN MOVEMENT DISORDERS, 2010, 90 :121-146
[8]   Proposed Neuroimaging Criteria for the Diagnosis of Multiple System Atrophy [J].
Brooks, David J. ;
Seppi, Klaus .
MOVEMENT DISORDERS, 2009, 24 (07) :949-964
[9]   Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy [J].
Brown, Richard G. ;
Lacomblez, Lucette ;
Landwehrmeyer, Bernard G. ;
Bak, Thomas ;
Uttner, Ingo ;
Dubois, Bruno ;
Agid, Yves ;
Ludolph, Albert ;
Bensimon, Gilbert ;
Payan, Christine ;
Leigh, Nigel P. .
BRAIN, 2010, 133 :2382-2393
[10]   Pontine MRI hyperintensities ("the cross sign") are not pathognomonic for multiple system atrophy (MSA) [J].
Bürk, K ;
Skalej, M ;
Dichgans, J .
MOVEMENT DISORDERS, 2001, 16 (03) :535-536
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