Osirisynes A-F, highly oxygenated polyacetylenes from the sponge Haliclona osiris

被引：42
作者：
Shin, JH
Seo, YW
Cho, KW
Rho, JR
Paul, VJ
机构：
[1] Korea Ocean Res & Dev Inst, Marine Nat Prod Lab, Seoul 425600, South Korea
[2] Univ Guam, Marine Lab, Mangilao, GU 96923 USA
来源：
TETRAHEDRON | 1998年 / 54卷 / 30期
关键词：
D O I：
10.1016/S0040-4020(98)00480-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Osirisynes A-F(1-6), highly oxygenated C-47 polyacetylenes have been isolated from the sponge Haliclona osiris collected from Guam. These compounds possess a diacetylenic carbinol and an a-acetylenic carboxylic acid as common structural features. The structures of osirisynes have been determined by combined spectroscopic methods. These compounds exhibited moderate cytotoxicity and inhibitory activities against Na+/K+-ATPase and reverse transcriptase (RT). (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8711 / 8720
页数：10
相关论文
共 19 条
[1]   MINOR BIOACTIVE POLYACETYLENES FROM PETROSIA-FICIFORMIS [J].
CIMINO, G ;
DEGIULIO, A ;
DEROSA, S ;
DIMARZO, V .
JOURNAL OF NATURAL PRODUCTS, 1990, 53 (02) :345-353
[2]  
COLIN PL, 1995, TROPICAL PACIFIC INV
[3]   Triangulynes A-H and triangulynic acid, new cytotoxic polyacetylenes from the marine sponge Pellina triangulata [J].
Dai, JR ;
Hallock, YF ;
Cardellina, JH ;
Gray, GN ;
Boyd, MR .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (09) :860-865
[4]   Vasculyne, a new cytotoxic acetylenic alcohol from the marine sponge Cribrochalina, vasculum [J].
Dai, JR ;
Hallock, YF ;
Cardellina, JH ;
Boyd, MR .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (01) :88-89
[5]   Marine natural products [J].
Faulkner, DJ .
NATURAL PRODUCT REPORTS, 1997, 14 (03) :259-302
[6]   New acetylenic metabolites from the marine sponge Pellina triangculata [J].
Fu, X ;
Abbas, SA ;
Schmitz, FJ ;
Vidavsky, I ;
Gross, ML ;
Laney, M ;
Schatzman, RC ;
Cabuslay, RD .
TETRAHEDRON, 1997, 53 (03) :799-814
[7]   BIOACTIVE MARINE METABOLITES .20. PETROSYNOL AND PETROSYNONE, ANTIMICROBIAL C30 POLYACETYLENES FROM THE MARINE SPONGE PETROSIA SP - DETERMINATION OF THE ABSOLUTE-CONFIGURATION [J].
FUSETANI, N ;
SHIRAGAKI, T ;
MATSUNAGA, S ;
HASHIMOTO, K .
TETRAHEDRON LETTERS, 1987, 28 (37) :4313-4314
[8]   BIOACTIVE MARINE METABOLITES .21. H,K-ATPASE INHIBITORS FROM THE MARINE SPONGE SIPHONOCHALINA-TRUNCATA - ABSOLUTE-CONFIGURATION OF SIPHONODIOL AND 2 RELATED METABOLITES [J].
FUSETANI, N ;
SUGANO, M ;
MATSUNAGA, S ;
HASHIMOTO, K .
TETRAHEDRON LETTERS, 1987, 28 (37) :4311-4312
[9]   ABSOLUTE STEREOCHEMISTRY OF PETROFORMYNES, HIGH-MOLECULAR POLYACETYLENES FROM THE MARINE SPONGE PETROSIA-FICIFORMIS [J].
GUO, YW ;
GAVAGNIN, M ;
TRIVELLONE, E ;
CIMINO, G .
TETRAHEDRON, 1994, 50 (46) :13261-13268
[10]   Antitumor activity and stereochemistry of acetylenic alcohols from the sponge Cribrochalina vasculum [J].
Hallock, YF ;
Cardellina, JH ;
Blaschak, MS ;
Alexander, MR ;
Prather, TR ;
Shoemaker, RH ;
Boyd, MR .
JOURNAL OF NATURAL PRODUCTS, 1995, 58 (12) :1801-1807
12