The role of interleukin-4 in the regulation of mouse primordial germ cell numbers

被引：42
|
作者：
Cooke, JE
Heasman, J
Wylie, CC
机构：
[1] UNIV CAMBRIDGE,WELLCOME CRC INST CANC & DEV BIOL,CAMBRIDGE CB2 1QR,ENGLAND
[2] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 1QR,ENGLAND
来源：
DEVELOPMENTAL BIOLOGY | 1996年 / 174卷 / 01期
基金：
英国惠康基金;
关键词：
D O I：
10.1006/dbio.1996.0047
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interleukin-4 (IL-4), a pleiotropic cytokine, stimulates a dose-dependent increase in the number of mouse primordial germ cells in culture. Results from bromodeoxyuridine incorporation assays suggest that IL-4 acts as a survival factor rather than as a mitogen for primordial germ cells in this system. Studies on the embryonic expression patterns of IL-4 and its receptors, using RT-PCR and ELISA, show that IL-4 and its receptors are present at the correct time and place to influence PGC numbers in vivo. (C) 1996 Academic Press, Inc.
引用
收藏
页码：14 / 21
页数：8
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