Tumor treating fields in pediatric high-grade glioma

被引：16

作者：

Green, Adam L. ^{[1
,2
]}

Levy, Jean M. Mulcahy ^{[1
,2
]}

Vibhakar, Rajeev ^{[1
,2
]}

Hemenway, Molly ^{[1
,2
]}

Madden, Jennifer ^{[1
,2
]}

Foreman, Nicholas ^{[1
,2
]}

Dorris, Kathleen ^{[1
,2
]}

机构：

[1] Childrens Hosp Colorado, Program Neurooncol, Ctr Canc & Blood Disorders, 12800 E 19th Ave RC1-N,Mail Stop 8302, Aurora, CO 80045 USA

[2] Univ Colorado, Sch Med, Dept Pediat, Morgan Adams Fdn Pediat Brain Tumor Res Program, Anschutz Med Campus,12800 E 19th Ave RC1-N, Aurora, CO 80045 USA

来源：

CHILDS NERVOUS SYSTEM | 2017年 / 33卷 / 07期

关键词：

Case series; Glioblastoma; Novocure; Optune; GLIOBLASTOMA;

D O I：

10.1007/s00381-017-3431-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tumor treating fields (TTF) are alternating electric fields applied continuously to the scalp. The treatment is approved for both primary and recurrent supratentorial adult glioblastoma but unstudied in children. We report a feasibility case series of five pediatric high-grade glioma patients (ages 10-20 years) treated at our institution with TTF along with chemotherapy and/or radiation. Two patients began therapy at second recurrence and showed progressive disease. Two others were treated upfront after radiation therapy, and both showed partial responses. A fifth patient was treated at first recurrence and also showed a partial response. All five tolerated TTF well without treatment-limiting toxicities. The tolerability of TTF, combined with the adult data, justify a pediatric clinical trial.

引用

页码：1043 / 1045

页数：3

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