Electrospun mucosal wound dressings containing styptics for bleeding control

被引：17

作者：

Wyrwa, Ralf ^{[1
]}

Otto, Katja ^{[2
]}

Voigt, Sibylle ^{[2
]}

Enkelmann, Astrid ^{[2
]}

Schnabelrauch, Matthias ^{[1
]}

Neubert, Thomas ^{[2
]}

Schneider, Gerlind ^{[2
]}

机构：

[1] INNOVENT eV, Technol Twicklung, Jena, Germany

[2] Jena Univ Hosp, Dept Otorhinolaryngol, Klinikum 1, D-07747 Jena, Germany

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2018年 / 93卷

关键词：

Hemostasis; Mucosa wound healing; Electrospinning; Polylactide; Adrenaline; Tranexamic acid; DRUG-DELIVERY SYSTEM; TRANEXAMIC ACID; CONTROLLED-RELEASE; EPISTAXIS; NANOFIBERS; MATRIX; EPINEPHRINE; OCCLUDIN; FIBERS; SKIN;

D O I：

10.1016/j.msec.2018.07.066

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Two major aspects need to be focused to accelerate wound healing of mucosa! damages especially in the field of otorhinolaryngology. (i) The problem of application due to the small access during surgery, (ii) the fixation of the wound dressing to reveal a stable healing process. In the present work the high request to a mucosal wound dressing which additionally support hemostasis was addressed. We developed an electrospun fabric made of poly(L-lactide-co-D/L-lactide) (PLA) which can be loaded with the hemostatic agents adrenaline and tranexamic acid to cover mucosal lesions analogues to common skin patches. These loaded electrospun fabrics were demonstrated to be biocompatible, thin and flexible, and thus could be adapted individually to the mucosal defect with respect to localization and size of the lesion. The treatment of mucosal defects with these loaded PIA wound dressings induced a faster and time controlled hemostatic reaction, which significantly improved the healing process.

引用

页码：419 / 428

页数：10

共 59 条

[1] Local use of tranexamic acid in ENT surgery [J].