Circular RNAs in hepatocellular carcinoma: Recent advances

被引：10

作者：

Niu, Zhao-Shan ^{[1
]}

Wang, Wen-Hong ^{[2
]}

机构：

[1] Qingdao Univ, Sch Basic Med, Lab Micromorphol, 1 Ningde Rd, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Sch Basic Med, Dept Pathol, Qingdao 266071, Shandong, Peoples R China

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2022年 / 14卷 / 06期

基金：

英国科研创新办公室;

关键词：

Hepatocellular carcinoma; Circular RNAs; Function; Diagnosis; Biomarkers; Targeted therapy; NONCODING RNA; SORAFENIB RESISTANCE; SIGNALING PATHWAY; HEPATOMA-CELLS; CIRCRNA; PROGRESSION; PROLIFERATION; CISPLATIN; ROLES; METASTASIS;

D O I：

10.4251/wjgo.v14.i6.1067

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNAs (circRNAs) have covalently closed loop structures at both ends, exhibiting characteristics dissimilar to those of linear RNAs. Emerging evidence suggests that aberrantly expressed circRNAs play crucial roles in hepatocellular carcinoma (HCC) by affecting the proliferation, apoptosis and invasive capacity of HCC cells. Certain circRNAs may be used as biomarkers to diagnose and predict the prognosis of HCC. Therefore, circRNAs are expected to become novel biomarkers and therapeutic targets for HCC. Herein, we briefly review the characteristics and biological functions of circRNAs, focusing on their roles in HCC to provide new insights for the early diagnosis and targeted therapy of HCC.

引用

页码：1067 / 1085

页数：19

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