In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application

被引：131
作者：
Prakash, J. [1 ]
Venkataprasanna, K. S. [1 ]
Bharath, G. [2 ]
Banat, Fawzi [2 ]
Niranjan, R. [1 ]
Venkatasubbu, G. Devanand [1 ]
机构：
[1] SRM Inst Sci & Technol, Dept Nanotechnol, Kattankulathur 603203, Tamil Nadu, India
[2] Khalifa Univ Sci & Technol, Dept Chem Engn, POB 127788, Abu Dhabi, U Arab Emirates
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2021年 / 627卷
关键词：
Wound dressing materials; Cellulose acetate (CA) nanofiber; Curcumin; Hemocompatible; Cell proliferation; NANOCOMPOSITE; COMPOSITE; CURCUMIN; CHITOSAN; DAMAGE; PH;
D O I：
10.1016/j.colsurfa.2021.127166
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electmspinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitm analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.
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页数：12
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