In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application

被引：131
作者：
Prakash, J. [1 ]
Venkataprasanna, K. S. [1 ]
Bharath, G. [2 ]
Banat, Fawzi [2 ]
Niranjan, R. [1 ]
Venkatasubbu, G. Devanand [1 ]
机构：
[1] SRM Inst Sci & Technol, Dept Nanotechnol, Kattankulathur 603203, Tamil Nadu, India
[2] Khalifa Univ Sci & Technol, Dept Chem Engn, POB 127788, Abu Dhabi, U Arab Emirates
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2021年 / 627卷
关键词：
Wound dressing materials; Cellulose acetate (CA) nanofiber; Curcumin; Hemocompatible; Cell proliferation; NANOCOMPOSITE; COMPOSITE; CURCUMIN; CHITOSAN; DAMAGE; PH;
D O I：
10.1016/j.colsurfa.2021.127166
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electmspinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitm analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.
引用
收藏
页数：12
相关论文
共 50 条
[31]   Microstructure and antibacterial efficacy of graphene oxide nanocomposite fibres [J].
Matharu, Rupy Kaur ;
Tabish, Tanveer A. ;
Trakoolwilaiwan, Thithawat ;
Mansfield, Jessica ;
Moger, Julian ;
Wu, Tongfei ;
Lourenco, Claudio ;
Chen, Biqiong ;
Ciric, Lena ;
Parkin, Ivan P. ;
Edirisinghe, Mohan .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2020, 571 :239-252
[32]   The effect of graphene-poly(methyl methacrylate) fibres on microbial growth [J].
Matharu, Rupy Kaur ;
Porwal, Harshit ;
Ciric, Lena ;
Edirisinghe, Mohan .
INTERFACE FOCUS, 2018, 8 (03)
[33]   PVA/SA/TiO2-CUR patch for enhanced wound healing application: In vitro and in vivo analysis [J].
Niranjan, R. ;
Kaushik, M. ;
Selvi, R. Thamarai ;
Prakash, J. ;
Venkataprasanna, K. S. ;
Prema, D. ;
Pannerselvam, Balashanmugam ;
Venkatasubbu, G. Devanand .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 138 :704-717
[34]   Enhanced wound healing by PVA/Chitosan/Curcumin patches: In vitro and in vivo study [J].
Niranjan, R. ;
Kaushik, M. ;
Prakash, J. ;
Venkataprasanna, K. S. ;
Christy, Arpana ;
Pannerselvam, Balashanmugam ;
Venkatasubbu, G. Devanand .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 182
[35]   γ-Radiation induced L-glutamic acid grafted highly porous, pH-responsive chitosan hydrogel beads: A smart and biocompatible vehicle for controlled anti-cancer drug delivery [J].
Nisar, Safiya ;
Pandit, Ashiq Hussain ;
Nadeem, Masood ;
Pandit, Altaf Hussain ;
Rizvi, M. Mushahid Alam ;
Rattan, Sunita .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 182 :37-50
[36]   The effects of pH on wound healing, biofilms, and antimicrobial efficacy [J].
Percival, Steven L. ;
McCarty, Sara ;
Hunt, John A. ;
Woods, Emma J. .
WOUND REPAIR AND REGENERATION, 2014, 22 (02) :174-186
[37]   Nanocomposite chitosan film containing graphene oxide/hydroxyapatite/gold for bone tissue engineering [J].
Prakash, J. ;
Prema, D. ;
Venkataprasanna, K. S. ;
Balagangadharan, K. ;
Selvamurugan, N. ;
Venkatasubbu, G. Devanand .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 154 :62-71
[38]   Investigations on the in-vivo toxicity analysis of reduced graphene oxide/TiO2 nanocomposite in zebrafish embryo and larvae (Danio rerio) [J].
Prakash, J. ;
Venkatesan, Manigandan ;
Prakash, Joy Sebastian J. ;
Bharath, G. ;
Anwer, Shoaib ;
Veluswamy, Pandiyarasan ;
Prema, D. ;
Venkataprasanna, K. S. ;
Venkatasubbu, G. Devanand .
APPLIED SURFACE SCIENCE, 2019, 481 :1360-1369
[39]   Investigation on photo-induced mechanistic activity of GO/TiO2hybrid nanocomposite against wound pathogens [J].
Prakash, Jayabal ;
Venkataprasanna, Kannan Sampath Kumar ;
Prema, Darmalingam ;
Sahabudeen, Sheik Mohideen ;
Debashree Banita, Samal ;
Venkatasubbu, Gopinath Devanand .
TOXICOLOGY MECHANISMS AND METHODS, 2020, 30 (07) :508-525
[40]   Photo induced mechanistic activity of GO/Zn(Cu)O nanocomposite against infectious pathogens: Potential application in wound healing [J].
Prema, D. ;
Binu, Nikita Mariam ;
Prakash, J. ;
Venkatasubbu, G. Devanand .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2021, 34
12345