In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application

被引：131

作者：

Prakash, J. ^{[1
]}

Venkataprasanna, K. S. ^{[1
]}

Bharath, G. ^{[2
]}

Banat, Fawzi ^{[2
]}

Niranjan, R. ^{[1
]}

Venkatasubbu, G. Devanand ^{[1
]}

机构：

[1] SRM Inst Sci & Technol, Dept Nanotechnol, Kattankulathur 603203, Tamil Nadu, India

[2] Khalifa Univ Sci & Technol, Dept Chem Engn, POB 127788, Abu Dhabi, U Arab Emirates

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2021年 / 627卷

关键词：

Wound dressing materials; Cellulose acetate (CA) nanofiber; Curcumin; Hemocompatible; Cell proliferation; NANOCOMPOSITE; COMPOSITE; CURCUMIN; CHITOSAN; DAMAGE; PH;

D O I：

10.1016/j.colsurfa.2021.127166

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electmspinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitm analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.

引用

页数：12

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